189681-04-7

• 

• Basic information

  1. Product Name: 4-CHLORO-5-(2-THIENYL)THIENO[2,3-D]PYRIMIDINE
  2. Synonyms: 4-CHLORO-5-(2-THIENYL)THIENO[2,3-D]PYRIMIDINE;4-CHLORO-5-(THIOPHEN-2-YL)THIENO[2,3-D]PYRIMIDINE;BUTTPARK 30\08-40;4-Chloro-5-thien-2-ylthieno[2,3-d]pyrimidine;Thieno[2,3-d]pyrimidine,4-chloro-5-(2-thienyl)-
  3. CAS NO:189681-04-7
  4. Molecular Formula: C10H5ClN2S2
  5. Molecular Weight: 252.74
  6. EINECS: N/A
  7. Product Categories: N/A
  8. Mol File: 189681-04-7.mol
  9. Article Data: 4

• Chemical Properties

  1. Melting Point: 110 °C
  2. Boiling Point: 420.3 °C at 760 mmHg
  3. Flash Point: 208 °C
  4. Appearance: /
  5. Density: 1.52 g/cm³
  6. Vapor Pressure: 6.95E-07mmHg at 25°C
  7. Refractive Index: 1.732
  8. Storage Temp.: N/A
  9. Solubility: N/A
  10. CAS DataBase Reference: 4-CHLORO-5-(2-THIENYL)THIENO[2,3-D]PYRIMIDINE(CAS DataBase Reference)
  11. NIST Chemistry Reference: 4-CHLORO-5-(2-THIENYL)THIENO[2,3-D]PYRIMIDINE(189681-04-7)
  12. EPA Substance Registry System: 4-CHLORO-5-(2-THIENYL)THIENO[2,3-D]PYRIMIDINE(189681-04-7)

• Safety Data

  1. Hazard Codes: N/A
  2. Statements: N/A
  3. Safety Statements: S24/25:Avoid contact with skin and eyes.;
  4. WGK Germany:
  5. RTECS:
  6. HazardClass: N/A
  7. PackingGroup: N/A
  8. Hazardous Substances Data: 189681-04-7(Hazardous Substances Data)

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• 4-Chloro-5-(2-thienyl)thieno[2,3-d]pyrimidine

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• Dayang Chem (Hangzhou) Co.,Ltd.
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• Thieno[2,3-d]pyrimidine,4-chloro-5-(2-thienyl)-

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• Henan Allgreen Chemical Co.,Ltd
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• 4-Chloro-5-(2-thienyl)thieno[2,3-d]pyrimidine , 97%

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• 4-CHLORO-5-(THIOPHEN-2-YL)THIENO[2,3-D]PYRIMIDINECAS

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• Hangzhou Fandachem Co.,Ltd
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• ZHEJIANG JIUZHOU CHEM CO.,LTD
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• 3-chloro-6-ethyl-1-benzothiophene-2-carbohydrazide(SALTDATA: FREE) CAS NO.189681-04-7

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• Jilin haofei import and export trade Co.,Ltd
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• 4-Chloro-5-(2-thienyl)thieno[2,3-d]pyriMidine

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• Hangzhou Share Chemical Co., Ltd
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• Thieno[2,3-d]pyrimidine,4-chloro-5-(2-thienyl)-

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189681-04-7 Usage

General Description

4-CHLORO-5-(2-THIENYL)THIENO[2,3-D]PYRIMIDINE is a chemical compound with a molecular formula C10H5ClN2S2. It is a heterocyclic compound consisting of two fused thiophene rings and a pyrimidine ring, with a chlorine atom and a thienyl group attached to the central pyrimidine ring. 4-CHLORO-5-(2-THIENYL)THIENO[2,3-D]PYRIMIDINE has potential applications in the field of pharmaceuticals and agrochemicals due to its ability to act as a building block for the synthesis of various biologically active molecules. Its unique structure and properties make it a valuable intermediate in the development of new drugs and agrochemicals.

Check Digit Verification of cas no

The CAS Registry Mumber 189681-04-7 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,8,9,6,8 and 1 respectively; the second part has 2 digits, 0 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 189681-04:
(8*1)+(7*8)+(6*9)+(5*6)+(4*8)+(3*1)+(2*0)+(1*4)=187
187 % 10 = 7
So 189681-04-7 is a valid CAS Registry Number.

InChI:InChI=1/C10H5ClN2S2/c11-9-8-6(7-2-1-3-14-7)4-15-10(8)13-5-12-9/h1-5H

189681-04-7 Well-known Company Product Price

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• Alfa Aesar

• (H33610)  4-Chloro-5-(2-thienyl)thieno[2,3-d]pyrimidine, 97%   

• 189681-04-7

• 250mg

• 685.0CNY

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• Alfa Aesar

• (H33610)  4-Chloro-5-(2-thienyl)thieno[2,3-d]pyrimidine, 97%   

• 189681-04-7

• 1g

• 1906.0CNY

• Detail

• Alfa Aesar

• (H33610)  4-Chloro-5-(2-thienyl)thieno[2,3-d]pyrimidine, 97%   

• 189681-04-7

• 5g

• 6063.0CNY

• Detail

189681-04-7SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name	4-chloro-5-thiophen-2-ylthieno[2,3-d]pyrimidine

1.2 Other means of identification

Product number	-
Other names	4-chloro-5-(2-thienyl)thiopheno[2,3-d]pyrimidine

1.3 Recommended use of the chemical and restrictions on use

Identified uses	For industry use only.
Uses advised against	no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number	-
Service hours	Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:189681-04-7 SDS

189681-04-7Upstream product

• 276670-60-1 5′-amino-[2,3′-bithiophene]-4′-carbonitrile 
• 10432-44-7 2-[1-(thiophen-2-yl)ethylidene]malononitrile 
• 88-15-3 2-Acetylthiophene 
• 949526-33-4 5-(thiophene-2-yl)thieno[2,3-d]pyrimidine-4-yl amine 

189681-04-7Downstream Products

189681-04-7Relevant articles and documents

Discovery of thienopyrimidine-based FLT3 inhibitors from the structural modification of known IKKβ inhibitors

Park, Chun-Ho,Lee, Chulho,Yang, Jee Sun,Joe, Bo-Young,Chun, Kwangwoo,Kim, Hyuntae,Kim, Hye Yun,Kang, Jong Soon,Lee, Jangik I.,Kim, Myung-Hwa,Han, Gyoonhee

, p. 2655 - 2660 (2014/06/09)

Inactivation of the NF-κB signaling pathway by inhibition of IKKβ is a well-known approach to treat inflammatory diseases such as rheumatoid arthritis and cancer. Thienopyrimidine-based analogues were designed through modification of the known IKKβ inhibitor, SPC-839, and then biologically evaluated. The resulting analogues had good inhibitory activity against both nitric oxide and TNF-α, which are well-known inflammatory responses generated by activated NF-κB. However, no inhibitory activity against IKKβ was observed with these compounds. The thienopyrimidine-based analogues were subsequently screened for a target kinase, and FLT3, which is a potential target for acute myeloid leukemia (AML), was identified. Thienopyrimidine-based FLT3 inhibitors showed good inhibition profiles against FLT3 under 1 μM. Overall, these compounds represent a promising family of inhibitors for future development of a treatment for AML.

NOVEL THIENOPYRIMIDINE DERIVATIVES OR PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF, PROCESS FOR THE PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME

-

, (2010/11/28)

The present invention relates to a novel thienopyrimidine derivative having an excellent anti? inflammatory and anti-cancer activity, or a pharmaceutically acceptable salt thereof, a process for the preparation thereof and a pharmaceutical composition comprising the same. The compound according to the present invention strongly inhibits IKB kinase-β (IKK-β) involved in the activation of a transcriptional factor, NF-κB, which is associated with inducing various immune and inflammatory diseases, whereby a composition comprising the compound is a useful therapeutic agent against inflammatory diseases, in particular, arthritis and cancer.

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