19026-80-3 Usage
General Description
ADAMANTAN-1-YL-ACETIC ACID HYDRAZIDE is a chemical compound that is used in the pharmaceutical industry for the synthesis of potential antiviral and antitumor agents. It is also used in the study of medicinal chemistry and drug design. The compound has potential therapeutic applications due to its ability to inhibit certain enzyme pathways and biological processes. It is a hydrazide derivative of adamantane, a bulky diamondoid hydrocarbon, which gives it unique properties and potential for use in various pharmaceutical and medical applications.
Check Digit Verification of cas no
The CAS Registry Mumber 19026-80-3 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,9,0,2 and 6 respectively; the second part has 2 digits, 8 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 19026-80:
(7*1)+(6*9)+(5*0)+(4*2)+(3*6)+(2*8)+(1*0)=103
103 % 10 = 3
So 19026-80-3 is a valid CAS Registry Number.
InChI:InChI=1/C12H20N2O/c13-14-11(15)7-12-4-8-1-9(5-12)3-10(2-8)6-12/h8-10H,1-7,13H2,(H,14,15)
19026-80-3Relevant articles and documents
Synthesis and Evaluation of Nifurtimox–Adamantane Adducts with Trypanocidal Activity
Foscolos, Angeliki-Sofia,Papanastasiou, Ioannis,Tsotinis, Andrew,Taylor, Martin C.,Kelly, John M.
supporting information, p. 1227 - 1231 (2019/07/09)
The synthesis and pharmacological evaluation of C1-substituted adamantane hydrazones, their C2-substituted isomers, and C1-substituted adamantane furanoic carboxamides is described. These new adamantane derivatives exhibited an interesting pharmacological profile in terms of trypanocidal activity and selectivity. The most active adduct with the best selectivity in this study was found to be the phenylacetoxy hydrazone 1 b (2-[4-(tricyclo[3.3.1.13,7]dec-1-yl)phenyl]-N′-[(5-nitrofuran-2-yl)methylene]acetohydrazide; EC50=11±0.9 nm, SITb=770).