191602-42-3Relevant articles and documents
BETA-SUBSTITUTED BETA-AMINO ACIDS AND ANALOGS AS CHEMOTHERAPEUTIC AGENTS AND USES THEREOF
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Paragraph 0842, (2017/02/28)
β-Substituted β-amino acids, β-substituted β-amino acid derivatives, and β-substituted β-amino acid analogs and (bio)isosteres and their use as chemotherapeutic agents are disclosed. The β-substituted β-amino acid derivatives and β-substituted β-amino acid analogs and (bio)isosteres are selective LAT1/4F2hc substrates and exhibit rapid uptake and retention in tumors expressing the LAT1/4F2hc transporter. Methods of synthesizing the β-substituted β-amino acid derivatives and β-substituted β-amino acid analogs and methods of using the compounds for treating cancer are also disclosed. The β-substituted β-amino acid derivatives and β-substituted β-amino acid analogs exhibit selective uptake in tumor cells expressing the LAT1/4F2hc transporter and accumulate in cancerous cells when administered to a subject in vivo. The β-substituted β-amino acid derivatives and β-substituted β-amino acid analogs and (bio)isosteres exhibit cytotoxicity toward several tumor types.
Activated pyridinium-tagged ruthenium complexes as efficient catalysts for ring-closing metathesis
Rix, Diane,Clavier, Hervé,Coutard, Yann,Gulajski, Lukasz,Grela, Karol,Mauduit, Marc
, p. 5397 - 5405 (2007/10/03)
New pyridinium-tagged ruthenium catalysts have been synthesised to perform olefin metathesis in several media including both organic and aqueous solvents and room temperature ionic liquids (RTILs). High activity was obtained in the ring-closing metathesis (RCM) of a variety of di- or tri-substituted and/or oxygen-containing dienes. However, only fair levels of recycling combined with low to moderate residual ruthenium levels (25-173 ppm) have been observed showing clearly the difficulty of associating high activity and recyclability.
