191732-76-0 Usage
Description
5-amino-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione is a thalidomide analog, which is a type of chemical compound that has been found to be useful in the field of protein degradation research, specifically in the development of proteolysis-targeting chimeras (PROTACs). These chimeras are designed to selectively degrade target proteins within cells, which can be a promising approach for the treatment of various diseases.
Uses
Used in Pharmaceutical Industry:
5-amino-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione is used as a research compound for the development of novel protein degradation therapies. Its application in this field is due to its structural similarity to thalidomide, which allows it to be utilized in the design and synthesis of new PROTACs that can selectively target and degrade specific proteins involved in disease pathways.
Used in Research and Development:
In the context of research and development, 5-amino-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione serves as a valuable tool for scientists to study the mechanisms of protein degradation and to identify potential therapeutic targets for various diseases. Its use in this application is driven by the need to develop innovative and effective treatments that can address unmet medical needs.
Used in Drug Discovery:
5-amino-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione is also used in drug discovery efforts, where it can be employed to identify new lead compounds with potential therapeutic applications. Its use in this area is based on its ability to modulate protein degradation pathways, which can provide insights into the development of new drugs that can target specific proteins for degradation, thereby offering a new approach to treating diseases.
Check Digit Verification of cas no
The CAS Registry Mumber 191732-76-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,9,1,7,3 and 2 respectively; the second part has 2 digits, 7 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 191732-76:
(8*1)+(7*9)+(6*1)+(5*7)+(4*3)+(3*2)+(2*7)+(1*6)=150
150 % 10 = 0
So 191732-76-0 is a valid CAS Registry Number.
191732-76-0Relevant articles and documents
Facile synthesis of an azido-labeled thalidomide analogue
Capitosti, Scott M.,Hansen, Todd P.,Brown, Milton L.
, p. 2865 - 2867 (2003)
(Matrix presented) A five-step synthesis of an azido-thalidomide analogue is presented. The sequence requires cheap and readily available starting materials and reagents, and only two steps require purification. Additionally, the azido-labeled analogue possesses activity comparable to that of thalidomide in inhibiting the proliferation of human microvascular endothelial cells, thus providing impetus for its use as a potential photoaffinity label of thalidomide.
Compound for targeted degradation of adhesion spot kinase and application thereof (by machine translation)
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Paragraph 0084-0085; 0092, (2020/11/23)
The invention belongs to the technical field of medicines, and provides a compound as shown in general formula (I) and geometric isomers or pharmaceutically acceptable salts, hydrates, solvates, prodrugs and a preparation method thereof. The compound has good degradation activity on the adhesion spot kinase (FAK). The compounds, and geometric isomers or pharmaceutically acceptable salts, hydrates, solvates or prodrugs thereof are as shown in the general formula I, wherein Y, L, X, Z, R1 What is claimed is: the claims and the description. (by machine translation)
REGULATING CHIMERIC ANTIGEN RECEPTORS
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Page/Page column 297; 300; 301, (2018/09/08)
This invention is in the area of compositions and methods for regulating chimeric antigen receptor immune effector cell, for example T-cell (CAR-T), therapy to modulate associated adverse inflammatory responses, for example, cytokine release syndrome and tumor lysis syndrome, using targeted protein degradation.
