194344-13-3Relevant articles and documents
Synthesis and Solid State 13C and 19F NMR Characterization of Aliphatic and Aromatic Carboxylic Acid Fluoride Polymers
Hagaman, Edward W.,Lee, Suk Kyu,Britt, Phillip F.
, p. 3950 - 3958 (1997)
A new chemical/spectroscopic couple that differentiates aromatic from aliphatic carboxylic acid polymers was developed. The method is complementary to more traditional methods of identification (IR) and is applicable to the analysis of complex mixtures wh
METHOD AND REAGENT FOR DEOXYFLUORINATION
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Paragraph 0111-0112; 0114; 0127, (2021/05/29)
A safe, simple, and selective method and reagent for deoxyfluorination is disclosed. With the method and reagent disclosed herein, organic compounds such as carboxylic acids, carboxylates, carboxylic acid anhydrides, aldehydes, and alcohols can be fluorinated by using the most common nucleophilic fluorinating reagents and electron deficient fluoroarenes as mediators under mild conditions, giving corresponding fluoroorganic compounds in excellent yield with a wide range of functional group compatibility and easy product purification. For example, directly utilizing KF for deoxyfluorination of carboxylic acids provides the most economical and the safest pathway to access acyl fluorides, key intermediates for syntheses of peptide, amide, ester, and dry fluoride salts.