194785-18-7Relevant articles and documents
Preparation process of carboxyl-X-rhodamine
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Paragraph 0069-0070, (2022/03/27)
The invention provides a preparation process of carboxyl-X-rhodamine, which adopts 8-hydroxyjulolidine phenol and trimellitic anhydride as raw materials, an intermediate 5, 6-carboxyl-X-rhodamine is synthesized by a direct cyclization method, a high-boiling-point solvent is adopted as a cyclization medium, and a cyclization product has poor solubility in the solvent and can be precipitated in a reaction system, so that the yield of 5, 6-carboxyl-X-rhodamine is increased, and the yield of 5, 6-carboxyl-X-rhodamine is increased. Therefore, the reaction conversion rate and the purification simplicity are obviously improved; 5, 6-carboxyl-X-rhodamine and organic amine are salified, so that the separation cost is greatly reduced, the operation steps are simplified, and the industrial production of carboxyl-X-rhodamine becomes possible; an acid precipitation method is adopted, the 5-carboxyl-X-rhodamine ammonium salt and the 6-carboxyl-X-rhodamine ammonium salt are converted into the 5-carboxyl-X-rhodamine and the 6-carboxyl-X-rhodamine, and the efficiency is high; the whole preparation process has the advantages of simplicity and convenience in operation, low equipment requirement, low cost, high equipment use efficiency and the like, and meets the requirements of industrial production and application.
Compounds and Method for Imaging Cancer
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, (2018/10/21)
A compound, a method of imaging a cell, and a method of detecting a cancer, an inflammatory disease, or a neoplastic disease are provided. The compound includes a nitroxide derivative of a fluorophore that is activatable upon exposure to free radicals. The method of imaging a cell includes contacting the cell with an activatable nitroxide derivative of a fluorophore. The method of detecting a cancer, an inflammatory disease, or a neoplastic disease includes administering an activatable nitroxide derivative of a fluorophore and then imaging one or more cells contacted with the compound.
METHODS FOR SYNTHESIZING RHODAMINE DYES
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Paragraph 0101, (2017/05/17)
Described herein are methods for the regioselective synthesis of substituted rhodamine dyes.
