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194810-35-0

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194810-35-0 Usage

Chemical class

Benzimidazole derivatives Piflufelastat belongs to a group of chemical compounds derived from benzimidazole.

Target enzyme

Phosphodiesterase 4 (PDE4) Piflufelastat is a potent and selective inhibitor of PDE4, an enzyme involved in the regulation of inflammatory processes.

Therapeutic potential

Inflammatory disorders and respiratory diseases Due to its PDE4 inhibitory activity, Piflufelastat is a promising candidate for the treatment of conditions such as asthma and chronic obstructive pulmonary disease (COPD).

Structure

Phenylene group and piperazinyl moiety The unique structure of Piflufelastat, containing these two functional groups, contributes to its high affinity and specificity for PDE4.

Mechanism of action

Inhibition of PDE4 activity Piflufelastat works by inhibiting the activity of PDE4, which in turn increases the levels of cyclic AMP (cAMP) in cells. This leads to the suppression of inflammation and reduction of airway obstruction in respiratory conditions.

Application

Managing inflammation and airway obstruction By targeting PDE4, Piflufelastat has the potential to alleviate symptoms associated with respiratory conditions, such as inflammation and airway obstruction.

Drug development

Potential therapeutic option Piflufelastat's ability to inhibit PDE4 makes it a valuable compound for further research and development as a therapeutic agent for treating respiratory diseases and other inflammatory conditions.

Check Digit Verification of cas no

The CAS Registry Mumber 194810-35-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,9,4,8,1 and 0 respectively; the second part has 2 digits, 3 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 194810-35:
(8*1)+(7*9)+(6*4)+(5*8)+(4*1)+(3*0)+(2*3)+(1*5)=150
150 % 10 = 0
So 194810-35-0 is a valid CAS Registry Number.

194810-35-0SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name 6-(4-methylpiperazin-1-yl)-2-[4-[6-(4-methylpiperazin-1-yl)-1H-benzimidazol-2-yl]phenyl]-1H-benzimidazole

1.2 Other means of identification

Product number -
Other names 1H-Benzimidazole,2,2'-(1,4-phenylene)bis[5-(4-methyl-1-piperazinyl)

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:194810-35-0 SDS

194810-35-0Upstream product

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