19525-87-2Relevant articles and documents
Gram-Scale Solution-Phase Synthesis of Heptapeptide Side Chain of Teixobactin 1
Chandrasekhar, Srivari,Donikela, Sangeetha,Mainkar, Prathama S.,Nayani, Kiranmai,Nomula, Vishnuvardhan
supporting information, p. 2268 - 2272 (2019/12/11)
We report herein a scalable synthesis of linear heptapeptide side chain of the depsipeptide natural product teixobactin through solution phase. The synthesis of heptapeptide was achieved through an efficient coupling of suitably protected tripeptide and tetrapeptide comprising of three d-amino acids and four usual l-amino acid subunits.
Continuous multiple liquid-liquid separation: Diazotization of amino acids in flow
Hu, Dennis X.,O'Brien, Matthew,Ley, Steven V.
supporting information; experimental part, p. 4246 - 4249 (2012/10/08)
A second-generation laboratory-scale, modular liquid-liquid separation device based on computer-controlled high-pressure pumps and a high-resolution digital camera has been invented. The diazotization of amino acids to produce valuable chiral hydroxyacids is demonstrated in flow for the first time. The use of a triple-separator system in conjuction with the developed diazotization process allows the safe and efficient production and automated isolation of multigram quantities of valuable chiral hydroxyacids.
New efficient enantioselective synthesis of 2-oxopiperazines: a practical access to chiral 3-substituted 2-oxopiperazines
Lencina, Claiton Leoneti,Dassonville-Klimpt, Alexandra,Sonnet, Pascal
, p. 1689 - 1697 (2008/12/21)
The development of efficient and stereoselective methods to produce 1,4-disubstituted-2-oxopiperazine in enantiomerically pure form, from a readily available starting material is crucial. Herein, we report a reduction modification to our previously descri
