195375-68-9Relevant articles and documents
A new approach to oligonucleotide N3′ → P5′ phosphoramidate building blocks
Zielinska, Daria,Pongracz, Krisztina,Gryaznov, Sergei M.
, p. 4495 - 4499 (2007/10/03)
A new synthetic approach to 5′-phosphoramidites of 3′-aminonucleosides was developed. The methodology relies upon the use of 3′-amino-2′,3′-dideoxynucleosides as the key starting materials. The final products were obtained in high yields via 2-3-step processes using selective introduction of orthogonal protective groups to the 3′-aminonucleoside sugar and base moieties.
A new approach to oligonucleotide N3′-→P5′ phosphoramidate building blocks
Zielinska, Daria,Pongracz, Krisztina,Gryaznov, Sergei
, p. 1063 - 1067 (2007/10/03)
A new synthetic approach to 5′-phosphoramidites of 3′-aminonucleosides was developed. The methodology relies upon the use of 3′-amino-2′,3′-dideoxy nucleosides as the key starting materials. The final phosphoramidite products were obtained with high yields via 2-3-step efficient chemical transformations using selective introduction of orthogonal protective groups to the 3′-aminonucleoside sugar and base moieties. Copyright Taylor & Francis, Inc.