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19555-48-7

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19555-48-7 Usage

General Description

"5-NITRO-2-(1-PYRROLIDINYL)BENZENECARBOXYLIC ACID" is a chemical compound with a molecular formula of C14H14N2O4. It is a nitro-substituted aromatic carboxylic acid derivative that contains a pyrrolidine group. 5-NITRO-2-(1-PYRROLIDINYL)BENZENECARBOXYLIC ACID is often used in pharmaceutical research as a building block for the synthesis of various drug candidates. It has potential applications in the development of anti-inflammatory and anti-cancer drugs due to its ability to modulate inflammatory and immune responses. The compound's unique molecular structure makes it a valuable tool for medicinal chemistry research. Despite its potential therapeutic uses, it is important to handle this compound with care due to its potential toxicity and adverse effects.

Check Digit Verification of cas no

The CAS Registry Mumber 19555-48-7 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,9,5,5 and 5 respectively; the second part has 2 digits, 4 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 19555-48:
(7*1)+(6*9)+(5*5)+(4*5)+(3*5)+(2*4)+(1*8)=137
137 % 10 = 7
So 19555-48-7 is a valid CAS Registry Number.
InChI:InChI=1/C11H12N2O4/c14-11(15)9-7-8(13(16)17)3-4-10(9)12-5-1-2-6-12/h3-4,7H,1-2,5-6H2,(H,14,15)/p-1

19555-48-7SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name 5-nitro-2-pyrrolidin-1-ylbenzoic acid

1.2 Other means of identification

Product number -
Other names 5-nitro-2-pyrrolidino-benzoic acid

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:19555-48-7 SDS

19555-48-7Relevant articles and documents

Discovery of novel N-benzylbenzamide derivatives as tubulin polymerization inhibitors with potent antitumor activities

Zhu, Huajian,Li, Wenlong,Shuai, Wen,Liu, Yang,Yang, Limei,Tan, Yuchen,Zheng, Tiandong,Yao, Hong,Xu, Jinyi,Zhu, Zheying,Yang, Dong-Hua,Chen, Zhe-Sheng,Xu, Shengtao

, (2021/03/08)

A series of novel N-benzylbenzamide derivatives were designed and synthesized as tubulin polymerization inhibitors. Among fifty-one target compounds, compound 20b exhibited significant antiproliferative activities with IC50 values ranging from 12 to 27 nM against several cancer cell lines, and possessed good plasma stability and satisfactory physicochemical properties. Mechanism studies demonstrated that 20b bound to the colchicine binding site and displayed potent anti-vascular activity. Notably, the corresponding disodium phosphate 20b-P exhibited an excellent safety profile with the LD50 value of 599.7 mg/kg (i.v. injection), meanwhile, it significantly inhibited tumor growth and decreased microvessel density in liver cancer cell H22 allograft mouse model without obvious toxicity. Collectively, 20b and 20b-P are novel promising anti-tubulin agents with more druggable properties and deserve to be further investigated for cancer therapy.

Ultrasound-promoted reaction of 2-chlorobenzoic acids and aliphatic amines

Docampo, Maite L.,Pellon, Rolando F.,Estevez-Braun, Ana,Ravelo, Angel G.

, p. 4111 - 4115 (2008/02/13)

An improvement to the use of DMF as a solvent for the condensation of 2-chlorobenzoic acids with aliphatic primary or secondary amines was described. A number of alkylaminobenzoic acids and dialkylaminobenzoic acids were synthesized in acceptable-to-good yield. The advantages of this procedure include readily available substrates, the use of an inexpensive copper powder without taking any precautions to exclude moisture under mild conditions and experimental ease. Furthermore, this condensation could also be achieved under nonclassical conditions by using ultrasonic irradiation at room temperature. We demonstrated that ultrasound-promoted condensation of 2-chlorobenzoic acid with aliphatic amines with the use of DMF as the solvent, especially in the case of secondary amines, affords products in high yields and reduces the reaction time to minutes. The results proved to be highly reproducible because the relevant sonochemical parameters were rigorously controlled. Wiley-VCH Verlag GmbH & Co. KGaA, 2007.

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