1956-25-8 Usage
Manufacturing Process
Preparation of 5-Benzyloxytryptophan: 11 grams α-acetylamino-β-(5- benzyloxy-indolyl-3)-propionic acid was suspended in a solution of 12 grams sodium hydroxide in 90 ml water and refluxed for 24 hours. Charcoal was added to the resultant solution and the mixture filtered hot. 150 ml 2N hydrochloric acid was added to the filtrate at 70°C and 5-benzyloxytryptophan crystallized on cooling. After washing with water and drying in vacuo over silica gel, the amino acid (6.9 grams, 71%) had MP (sealed evacuated tube) 232°C, with softening, finally melting at 237° to 238°C (decomposition). Charcoal was added to the filtrate, which was filtered hot and adjusted to pH 2. On cooling a second crop of 5-benzyloxytryptophan was obtained (2.2 grams, 23%), MP (sealed evacuated tube) 230°C, with softening, finally melting at 233° to 237°C (decomposition). The overall yield of 5- benzyloxytryptophan was 9.1 grams (94%).
Check Digit Verification of cas no
The CAS Registry Mumber 1956-25-8 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 1,9,5 and 6 respectively; the second part has 2 digits, 2 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 1956-25:
(6*1)+(5*9)+(4*5)+(3*6)+(2*2)+(1*5)=98
98 % 10 = 8
So 1956-25-8 is a valid CAS Registry Number.
InChI:InChI=1/C18H18N2O3/c19-16(18(21)22)8-13-10-20-17-7-6-14(9-15(13)17)23-11-12-4-2-1-3-5-12/h1-7,9-10,16,20H,8,11,19H2,(H,21,22)
1956-25-8Relevant articles and documents
Synthesis of tryptophans
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, (2008/06/13)
The preparation of racemic and optically pure tryptophans is described. The D-enantiomers of the 6-substituted compounds possess a potent sweetening capability. Novel intermediates are also disclosed.
