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195601-01-5

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195601-01-5 Usage

Type of Compound

Methyl ester derivative of 1-aziridineacetic acid

Potential Applications

Biological and pharmaceutical applications

Use as a Precursor

In the synthesis of various pharmaceutical compounds and pesticides

Structural Features

2,2-dichloro-3,3-diphenyl substitution on the aziridine ring

Chemical and Biological Properties

Specific properties conferred by the 2,2-dichloro-3,3-diphenyl substitution

Check Digit Verification of cas no

The CAS Registry Mumber 195601-01-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,9,5,6,0 and 1 respectively; the second part has 2 digits, 0 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 195601-01:
(8*1)+(7*9)+(6*5)+(5*6)+(4*0)+(3*1)+(2*0)+(1*1)=135
135 % 10 = 5
So 195601-01-5 is a valid CAS Registry Number.

195601-01-5SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name methyl 2-(2,2-dichloro-3,3-diphenylaziridin-1-yl)acetate

1.2 Other means of identification

Product number -
Other names 1-Aziridineacetic acid,2,2-dichloro-3,3-diphenyl-,methyl ester

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:195601-01-5 SDS

195601-01-5Downstream Products

195601-01-5Relevant articles and documents

Cascade Transformations of (2,2-Diaryl-3,3-dichloroaziridin-1-yl)acetates

Khlebnikov,Novikov,Kusei,Kopf,Kostikov

, p. 559 - 573 (2007/10/03)

Esters of (2,2-diaryl-3,3-dichloroaziridin-1-yl)acetic acid prepared from glycine derivatives under alkylation conditions afford esters of 2-[N-alkyl-N-(2,2-diaryl-1-cyanovinyl)amino]-3,3-diarylacrylic acid in 20-40% yield. The reaction resulting in these compounds proceeds through a cascade of 3-chloro-2-azadiene and ylide intermediates. 3-Chloro-2-azadienes originating from (2,2-diaryl-3,3-dichloroaziridin-1-yl)-acetates react with primary and secondary amines at the carbon atom of imine group providing ketenimines which undergo ketenimine-nitrile rearrangement or fragmentation. The other bases (KOH, MeONa, DBU) effect dehydrochlorination of the mentioned 3-chloro-2-azadienes giving nitrile-ylides which are trapped by nucleophilic reagents. The 3-chloro-2-azadiene obtained from methyl (2,2-diaryl-3,3-dichloroaziridin-1-yl)- acetate and DBU was relatively stable and was isolated as an individual compound. (2,2-diaryl-3,3-dichloroaziridin-1-yl)propionates behave as nonfunctionalized dichloroaziridines.

A Facile Synthesis of New Ketenimine Derivatives of α-Amino Acids

Khlebnikov, Alexander F.,Novikov, Mikhail S.,Kostikov, Rafael R.

, p. 929 - 930 (2007/10/03)

N-Vinylidene α-amino acid derivatives have been prepared from the benzophenone Schiff bases of α-amino acid esters via dichlorocarbene addition to give gem-dichloroaziridine followed by ring opening and dechlorination.

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