19591-45-8Relevant articles and documents
Anthraquinones related to rhein inhibit glucose uptake into chondrocytes, a mechanism for anti-osteoarthritis drugs?
Carney, Stephen L.,Broadmore, Richard J.,Tomlinson, Rosemarie,Kingston, Ann,Gallagher, Peter T.,Owton, W. Martin,Miles, Martin V.,Brunavs, Michael,Smith, Colin W.,Hicks, Terry A.,Dobson, David R.,Steggles, David J.,Ambler, Samantha J.,Halliday, Kelly A.
, p. 817 - 822 (1997)
Rhein has been shown to inhibit the uptake of glucose into Ehrlich Ascites tumor cells. In this paper we show that a wide range of anthraquinones related to rhein can also inhibit glucose uptake into chondrocytes, many significantly more than the parent molecule.
Pharmaceutical compounds
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, (2008/06/13)
Pharmaceutical compounds of the formula STR1 in which R1 and R3 are each C1-4 alkyl or C1-4 alkyl-carbonyl, and R2 is carboxy, tetrazolyl, C1-4 alkyl-sulphonamido or --CR4 R5 CO2 H where R4 and R5 are each hydrogen or C1-4 alkyl; provided that when R1 and R3 are both methyl and when R1 and R3 are both methylcarbonyl, R2 is not carboxy; and salts and esters thereof.