195986-74-4 Usage
General Description
7-Bromo-1,4-benzodiazepin-2,5-dione is a chemical compound belonging to the benzodiazepine class. It is a derivative of 1,4-benzodiazepine and contains a bromine atom at the 7th position. 7-BROMO-1,4-BENZODIAZEPIN-2,5-DIONE has been studied for its potential pharmaceutical properties, including its use in the treatment of central nervous system disorders. Benzodiazepines are known for their ability to modulate the neurotransmitter gamma-aminobutyric acid (GABA) in the brain, leading to effects such as sedation, muscle relaxation, and anxiety relief. 7-Bromo-1,4-benzodiazepin-2,5-dione may have similar effects and is the subject of ongoing research for its potential therapeutic applications.
Check Digit Verification of cas no
The CAS Registry Mumber 195986-74-4 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,9,5,9,8 and 6 respectively; the second part has 2 digits, 7 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 195986-74:
(8*1)+(7*9)+(6*5)+(5*9)+(4*8)+(3*6)+(2*7)+(1*4)=214
214 % 10 = 4
So 195986-74-4 is a valid CAS Registry Number.
InChI:InChI=1/C9H7BrN2O2/c10-5-1-2-7-6(3-5)9(14)11-4-8(13)12-7/h1-3H,4H2,(H,11,14)(H,12,13)
195986-74-4Relevant articles and documents
Design and synthesis of novel 1,4-benzodiazepine derivatives and their biological evaluation as cholinesterase inhibitors
Mohamed, Lamia W.,El-Yamany, Mohamed F.
, p. 1369 - 1377 (2012)
A new series of 1,4-benzodiazepine-2,5-dione structurally related to cyclopenin has been synthesized. The new compounds were assayed in vivo and in vitro for their ability to inhibit acetylcholinesterase enzyme and were found to have potent reversible anticholinesterase activity when tested in vitro for isolated frog rectus abdominis and guinea pig ileum in addition to increasing brain cholinesterase level in rats when percentage inhibition were tested in vivo, moreover compounds 5a, 5b, 5c and 5g were the most active. LD50 was performed for these derivatives and they displayed high safety margin.
Synthesis and pharmacological activity of 1,4-benzodiazepine derivatives
Osman,El-Gendy,Omar,Wagdy,Omar
, p. 871 - 874 (2007/10/03)
3,4-Dihydro-1H-benzo[e][1,4]diazepine-2,5-dione 1 has been prepared from the reaction of glycine with isatoic anhydride. Bromination of 1 with molecular bromine in acetic acid affords the 7-bromo derivative 2. Partial and full reduction of 2 with LiAlHsu
