19615-48-6Relevant articles and documents
Lipoxygenase-catalyzed dehydration of furylhydroperoxides
Antonioletti,Bonadies,Monteagudo,Rossi,Scettri
, p. 1919 - 1920 (1992)
3-alkoxycarbonyl-5(1-hydroperoxyalkyl)-furans 1 are changed into the corresponding 5-acyl and 5-formyl derivatives 2 by a lipoxygenase-catalyzed process. The conversion shows to proceed in enantioselective way leading to chiral furylhydroperoxides and furylalcohols. 3-alkoxycarbonyl-5(1-hydroperoxyalkyl)-furans 1 are changed into the corresponding 5-acyl and 5-formyl derivatives 2 by a lipoxygenase-catalyzed process.
PIPERIDINE DERIVATIVES FOR USE IN THE TREATMENT OF PANCREATIC CANCER
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Page/Page column 63; 64, (2018/03/01)
The present invention relates to novel piperidine derivatives having better cell growth inhibitory activities toward cancer cell cultures and, more particularly, PANC-1 cancer cell cultures than FK866. Accordingly, the present invention relates to compoun
Rapid discovery of potent α-fucosidase inhibitors by in situ screening of a library of (pyrrolidin-2-yl)triazoles
Elias-Rodriguez, Pilar,Moreno-Clavijo, Elena,Carmona, Ana T.,Moreno-Vargas, Antonio J.,Robina, Inmaculada
supporting information, p. 5898 - 5904 (2014/08/05)
The synthesis of a small library of (pyrrolidin-2-yl)triazoles via copper catalysed cycloaddition of an alkynyl iminocyclopentitol and a set of commercial and synthetic azides has been achieved. The in situ screening for the activity towards α-fucosidase of the resulting triazoles has allowed the identification of one of the most potent and selective pyrrolidine derived inhibitors of this enzyme (Ki = 4 nM). This journal is the Partner Organisations 2014.
