19658-77-6Relevant articles and documents
Enantioselective Dearomative [3 + 2] Umpolung Annulation of N-Heteroarenes with Alkynes
Cui, Bing-Hui,Huang, Wen-Yu,Jia, Yi-Xia,Liang, Ren-Xiao,Liu, Hang,Liu, Jia-Liang,Wang, Qiang,Yang, Peng,Zhang, Xiao-Dong,Zhang, Yue-Yuan
supporting information, p. 1087 - 1093 (2022/02/09)
Enantioselective [3 + 2] annulation of N-heteroarenes with alkynes has been developed via a cobalt-catalyzed dearomative umpolung strategy in the presence of chiral ligand and reducing reagent. A variety of electron-deficient N-heteroarenes, including qui
An Unprecedented, Lewis Acid-Mediated, Metal-Free Iodoannulation Strategy to Aromatic Iodides
Banik, Trisha,Betkekar, Vipul V.,Kaliappan, Krishna P.
supporting information, p. 3676 - 3680 (2018/10/31)
A direct transformation of ortho-alkynylated aromatic vinyl ethers to 1-iodonaphthalenes and other iodo-heterocycles under mild Lewis acidic conditions in the presence of iodide as an external nucleophile is reported. The first example of an iodoannulation strategy using a nucleophilic source of iodine, coupled with good to excellent yields, exclusive alpha regioselectivity and a broad substrate scope makes this work an attractive avenue towards the construction of aromatic iodides.
Direct conversion of 1-(2-bromobenzoyl)isoquinolines to dibenzo[ de,g ]quinolin-7-ones via reductive photocyclization
Chuang, Ta-Hsien,Li, Chien-Fu,Lee, Hong-Zin,Wen, Yu-Chia
, p. 4974 - 4984 (2013/06/27)
A series of A/D-ring substituted dibenzo[de,g]quinolin-7-ones was produced from the corresponding isoquinolinones and (2-bromophenyl)acetonitriles in four steps. This represents a convenient approach toward the synthesis of tetracyclic alkaloids. A direct conversion of 1-(2-bromobenzoyl)isoquinolines to dibenzo[de,g]quinolin-7-ones is the key step in the total synthesis. The yield of the reductive photocyclization depends on the position of the substituents at the isoquinolyl ring and the phenyl group. The mechanism of the reductive photocyclization is also discussed.
