196716-19-5Relevant articles and documents
Exploration of [2 + 2 + 2] cyclotrimerisation methodology to prepare tetrahydroisoquinoline-based compounds with potential aldo-keto reductase 1C3 target affinity
Santos, Ana R. N.,Sheldrake, Helen M.,Ibrahim, Ali I. M.,Danta, Chhanda Charan,Bonanni, Davide,Daga, Martina,Oliaro-Bosso, Simonetta,Boschi, Donatella,Lolli, Marco L.,Pors, Klaus
, p. 1476 - 1480 (2019)
Tetrahydroisoquinoline (THIQ) is a key structural component in many biologically active molecules including natural products and synthetic pharmaceuticals. Here, we report on the use of transition-metal mediated [2 + 2 + 2] cyclotrimerisation of alkynes to generate tricyclic THIQs with potential to selectively inhibit AKR1C3.
Palladium-catalyzed coupling/cyclization reactions of allene-substituted lactams
Karstens, Willem F. J.,Rutjes, Floris P. J. T.,Hiemstra, Henk
, p. 6275 - 6278 (2007/10/03)
ω-(2,3-Butadienyl)lactams react with aryl iodides in the presence of n-Bu4NCl, K2CO3 and a catalytic amount of Pd(PPh3)4 to give bicyclic enamides resulting from attack of nitrogen on the central carbon and transfer of the aryl group to the terminal carbon and of the allene.
