196930-46-8Relevant articles and documents
Discovery of cysteine and its derivatives as novel antiviral and antifungal agents
Lu, Aidang,Shi, Li,Wang, Tienan,Wang, Ziwen,Yang, Shan,Zhou, Yanan
, (2021/06/25)
Based on the structure of the natural product cysteine, a series of thiazolidine-4-carboxylic acids were designed and synthesized. All target compounds bearing thiazolidine-4-carboxylic acid were characterized by1 H-NMR,13 C-NMR, and
GLUCOSE-SENSITIVE PEPTIDE HORMONES
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Page/Page column 26, (2020/01/11)
The present invention relates to a conjugate of the formula P-L-I, wherein P is a peptide hormone effecting the metabolism of carbohydrates in vivo, L is a hydrolysable linker molecule consisting of Lp and Lj, and I is a molecule capable of inhibiting the effect of the peptide hormone P on the metabolism of carbohydrates in vivo. Under in vivo conditions, the conjugate is the major compound. When the concentration of glucose increases in v/vo,the concentration of the peptide hormone effecting the metabolism of carbohydrates in vivo also increases.
Synthesis and in vitro studies of thiazolidine-4-carboxylic acid hydrazones as potential antitubercular agents
Nagasree, Kurre Puma,Kumar, Muthyala Murali Krishna,Prasad, Yejella Rajendra,Sriram, Dharmarajan,Yogeeswari, Perumal
, p. 538 - 555 (2019/05/21)
A series of forty six 2-substituted aryl-thiazolidine-4-carboxylic acid hydrazones (6a-c, 7a-c, 8a-c, 9a-c series) have been synthesized and isolated in their pure isomeric form (2R, 4R and 2S, 4R). Purity and structures have been ascertained by chromatographic and, IR, NMR and mass spectral data analysis. Antitubercular activity screening of these synthesized compounds against Mycobacterium tuberculosis H37Rv (MTB) and multi-drug resistant Mycobacterium tuberculosis (MDR-TB) has resulted in identification of three active compounds (6a 11, 6a 13, 6a 15) with MIC 10 μM against MTB and MDR-TB. The compound 6a 11 (2R, 4R isomer) shows the highest potency with MIC 1.33 μM against MDR-TB. It is observed that the antitubercular activity of 2R isomer is four times more than the corresponding 2S isomer.
