196965-14-7

• 

• Basic information

  1. Product Name: SB 221284
  2. Synonyms: 5-(METHYLTHIO)-1-(3-PYRIDYLCARBAMOYL)-6-(TRIFLUOROMETHYL)INDOLINE;2,3-DIHYDRO-5-(METHYLTHIO)-N-3-PYRIDINYL-6-(TRIFLUOROMETHYL)-1H-INDOLE-1-CARBOXAMIDE;SB 221284
  3. CAS NO:196965-14-7
  4. Molecular Formula: C16H14F3N3OS
  5. Molecular Weight: 353.36
  6. EINECS: N/A
  7. Product Categories: N/A
  8. Mol File: 196965-14-7.mol
  9. Article Data: 2

• Chemical Properties

  1. Melting Point: N/A
  2. Boiling Point: 536.2°C at 760 mmHg
  3. Flash Point: 278.1°C
  4. Appearance: white/solid
  5. Density: 1.43g/cm³
  6. Vapor Pressure: 1.43E-11mmHg at 25°C
  7. Refractive Index: 1.621
  8. Storage Temp.: Store at +4°C
  9. Solubility: DMSO: ~14 mg/mL, soluble
  10. CAS DataBase Reference: SB 221284(CAS DataBase Reference)
  11. NIST Chemistry Reference: SB 221284(196965-14-7)
  12. EPA Substance Registry System: SB 221284(196965-14-7)

• Safety Data

  1. Hazard Codes: N/A
  2. Statements: N/A
  3. Safety Statements: N/A
  4. WGK Germany: 3
  5. RTECS:
  6. HazardClass: N/A
  7. PackingGroup: N/A
  8. Hazardous Substances Data: 196965-14-7(Hazardous Substances Data)

• Suppliers
• Usage
• SDS
• Upstream product
• Downstream Products
• Article

196965-14-7 Suppliers

Recommended suppliersmore

• Product
• FOB Price
• Min.Order
• Supply Ability
• Supplier
• Contact Supplier

• 2,3-DIHYDRO-5-(METHYLTHIO)-N-3-PYRIDINYL-6-(TRIFLUOROMETHYL)-(1H)-INDOLE-1-CARBOXAMIDE

  Cas No: 196965-14-7

• USD $ 3.0-3.0 / Kilogram

• 1 Kilogram

• 1-100 Metric Ton/Month

• Dayang Chem (Hangzhou) Co.,Ltd.
• Contact Supplier

• Factory Supply High Quality CAS196965-14-7in buk with best price

  Cas No: 196965-14-7

• USD $ 393.0-665.0 / Kilogram

• 1 Kilogram

• 10000 Metric Ton/Month

• Baoji Guokang Healthchem co.,ltd
• Contact Supplier

• 2,3-Dihydro-5-(methylthio)-N-3-pyridinyl-6-(trifluoromethyl)-(1H)-indole-1-carboxamide

  Cas No: 196965-14-7

• No Data

• No Data

• 5

• Hangzhou J&H Chemical Co., Ltd.
• Contact Supplier

• 1H-Indole-1-carboxamide, 2,3-dihydro-5-(methylthio)-N-3-pyridinyl-6-(trifluoromethyl)-

  Cas No: 196965-14-7

• No Data

• No Data

• No Data

• Kono Chem Co.,Ltd
• Contact Supplier

• SB 221284

  Cas No: 196965-14-7

• No Data

• No Data

• No Data

• BOC Sciences
• Contact Supplier

• 2,3-DIHYDRO-5-(METHYLTHIO)-N-3-PYRIDINYL-6-(TRIFLUOROMETHYL)-(1H)-INDOLE-1-CARBOXAMIDE?

  Cas No: 196965-14-7

• No Data

• No Data

• No Data

• Hangzhou Fandachem Co.,Ltd
• Contact Supplier

• SB 221284

  Cas No: 196965-14-7

• No Data

• No Data

• No Data

• ZHEJIANG JIUZHOU CHEM CO.,LTD
• Contact Supplier

• 1H-Indole-1-carboxamide, 2,3-dihydro-5-(methylthio)-N-3-pyridinyl-6-(trifluoromethyl)-

  Cas No: 196965-14-7

• No Data

• No Data

• No Data

• Shanghai united Scientific Co.,Ltd.
• Contact Supplier

• SB 221284

  Cas No: 196965-14-7

• No Data

• No Data

• No Data

• Finetech Industry Limited
• Contact Supplier

• SB 221284;2,3-Dihydro-5-(Methylthio)-N-3-pyridinyl-6-(trifluoroMethyl)-1H-indole-1-carboxaMide

  Cas No: 196965-14-7

• No Data

• No Data

• No Data

• Wuxi Morality Chemical Co., Ltd
• Contact Supplier

196965-14-7 Usage

Uses

SB 221284 is a potent, selective SR-2C/SR-2B antagonist.

Biological Activity

Potent, selective 5-HT 2C/2B receptor antagonist. pK i values are 6.4, 7.9 and 8.6 for 5-HT 2A , 2B and 2C receptors respectively. Centrally active upon systemic administration in vivo .

Check Digit Verification of cas no

The CAS Registry Mumber 196965-14-7 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,9,6,9,6 and 5 respectively; the second part has 2 digits, 1 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 196965-14:
(8*1)+(7*9)+(6*6)+(5*9)+(4*6)+(3*5)+(2*1)+(1*4)=197
197 % 10 = 7
So 196965-14-7 is a valid CAS Registry Number.

InChI:InChI=1/C16H14F3N3OS/c1-24-14-7-10-4-6-22(13(10)8-12(14)16(17,18)19)15(23)21-11-3-2-5-20-9-11/h2-3,5,7-9H,4,6H2,1H3,(H,21,23)

196965-14-7SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name	5-methylsulfanyl-N-pyridin-3-yl-6-(trifluoromethyl)-2,3-dihydroindole-1-carboxamide

1.2 Other means of identification

Product number	-
Other names	5-(Methylthio)-1-(3-pyridylcarbamoyl)-6-(trifluoromethyl)indoline

1.3 Recommended use of the chemical and restrictions on use

Identified uses	For industry use only.
Uses advised against	no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number	-
Service hours	Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:196965-14-7 SDS

196965-14-7Upstream product

• 15268-31-2 3-Pyridyl isocyanate 
• 181513-42-8 2,3-dihydro-5-methylthio-6-trifluoromethyl-indole 
• 181513-36-0 1-[5-(1-Acetyl-6-trifluoromethyl-2,3-dihydro-1H-indol-5-yldisulfanyl)-6-trifluoromethyl-2,3-dihydro-indol-1-yl]-ethanone 
• 181513-33-7 bis[5-[6-(trifluoromethyl)indolinyl]] disulfide 
• 181513-39-3 1-(5-Methylsulfanyl-6-trifluoromethyl-2,3-dihydro-indol-1-yl)-ethanone 
• 181513-37-1 1-(5-Mercapto-6-trifluoromethyl-2,3-dihydro-indol-1-yl)-ethanone 
• 181513-32-6 5-Thiocyanato-6-trifluoromethyl-2,3-dihydro-1H-indole 
• 181513-29-1 6-trifluoromethyl-2,3-dihydro-1H-indole 
• 13544-43-9 6-(trifluoromethyl)-1H-indole 
• 4013-72-3 nicotinoyl azide 

196965-14-7Downstream Products

196965-14-7Relevant articles and documents

Novel and selective 5-HT(2C/2B) receptor antagonists as potential anxiolytic agents: Synthesis, quantitative structure - Activity relationships, and molecular modeling of substituted 1-(3- pyridylcarbamoyl)indolines

Bromidge, Steven M.,Dabbs, Steven,Davies, David T.,Duckworth, D. Malcolm,Forbes, Ian T.,Ham, Peter,Jones, Graham E.,King, Frank D.,Saunders, Damian V.,Starr, Susannah,Thewlis, Kevin M.,Wyman, Paul A.,Blaney, Frank E.,Naylor, Christopher B.,Bailey, Fiona,Blackburn, Thomas P.,Holland, Vicky,Kennett, Guy A.,Riley, Graham J.,Wood, Martyn D.

, p. 1598 - 1612 (2007/10/03)

The synthesis, biological activity, and molecular modeling of a novel series of substituted 1-(3-pyridylcarbamoyl)indolines are reported. These compounds are isosteres of the previously published indole urea 1 (SB- 206553) and illustrate the use of aromatic disubstitution as a replacement for fused five-membered rings in the context of 5-HT(2C/2B) receptor antagonists. By targeting a region of space previously identified as sterically allowed at the 5-HT(2C) receptor but disallowed at the 5-HT(2A) receptor, we have identified a number of compounds which are the most potent and selective 5-HT(2C/2B) receptor antagonists yet reported. 46 (SB-221284) was selected on the basis of its overall biological profile for further evaluation as a novel, potential nonsedating anxiolytic agent. A CoMFA analysis of these compounds produced a model with good predictive value and in addition good qualitative agreement with both our 5-HT(2C) receptor model and our proposed binding mode for this class of ligands within that model.

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 196965-14-7 SB 221284

Send

Send

Metric Ton KG G Pound L ML

Send

Send