197079-25-7Relevant articles and documents
Synthesis, characterization and molecular docking studies of some new 1,3,4-oxadiazolines bearing 6-methylpyridine moiety for antimicrobial property
Shyma,Kalluraya, Balakrishna,Peethambar,Telkar, Sandeep,Arulmoli
, p. 394 - 404 (2013)
A new series of 3-acetyl-2-aryl-2H/methyl-5-[3-(6-methylpyridinyl)]-2,3- dihydro-[1,3,4]-oxadiazole derivatives were synthesized from 6-methyl nicotinate through a multistep reaction sequence. The structures of newly synthesized compounds were established on the basis of elemental analysis, IR, 1H NMR, 13C NMR and mass spectral data. Three dimensional structure of the compound 5f was further confirmed by single crystal X-ray analysis. All the synthesized compounds were screened for their antimicrobial activity and antioxidant activity. The final compounds were subjected to molecular docking studies for the inhibition of enzyme l-glutamine: D-fructose-6-phosphate amidotransferase [GlcN-6-P] (EC 2.6.1.16). The in silico molecular docking results are matching with the in vitro studies and they may be considered as good inhibitor of GlcN-6-P synthase.6-methylpyridine.
1, 2, 4 - Oxadiazole Nrf2 activator - tacrine split product as well as preparation method and application thereof
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Paragraph 0025; 0098-0099; 0102, (2021/11/06)
The invention discloses 1,oxadiazole Nrf2 activator - tacrine split products as well as a preparation method and application thereof. The invention relates to an acetylcholinesterase inhibitory activity. Nrf2 Activation activity, selective screening and Morris water maze test was carried out to evaluate the compound of general formula I, II, III for the treatment of's disease (in particular, severe's disease), found to have good in vitro, in vivo activity and extremely high selectivity, and can be used as a precursor substance for further development through selective inhibition of acetylcholinesterase and activation Nrf2.
Applications of 3-aryl-1,2,4-triazole-5(4H)-thione imide as NA inhibitors
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Paragraph 0041-0044, (2017/11/04)
The invention discloses 3-aryl-1,2,4-triazole-5(4H)-thione imide derivatives shown as a general formula I, pharmaceutically acceptable salts thereof, a preparing method of the derivatives, medicine compositions and applications of the derivatives and the salts in preparation of influenza virus neuraminidase inhibitors. The formula I is shown in the specification, wherein Z is selected from N or CH, X is selected from H, C1-C2 alkyl, C3-C4 direct-chain alkyl or branch-chain alkyl, Y1 is selected from hydrogen, C1-C2 alkyl, hydroxy, a methoxy group or an ethoxy group, Y2 is selected from hydrogen, C1-C2 alkyl, hydroxy, a methoxy group or an ethoxy group, Y3 is selected from hydrogen, C1-C2 alkyl, hydroxy, an ethoxy group, amino, methylamino, dimethylamino, acetamido, fluorine, chlorine, bromine or iodine, Y4 is selected from hydrogen, C1-C2 alkyl, hydroxy, a methoxy group or an ethoxy group, and Y5 is selected from hydrogen or C1-C2 alkyl.