19717-25-0Relevant articles and documents
Copper-catalyzed domino synthesis of ynamines
Dasgupta, Priyabrata,Islam, Sk Shamim,Rao, Maddali L. N.
, p. 7855 - 7860 (2021/09/28)
The hitherto unexploredN-alkynylation of electron-withdrawing or protecting group free N-heteroarenes such as indole, carbazole and pyrrole was developed usinggem-dibromoalkenes to synthesize ynamines under ligand-free copper-catalyzed domino conditions. The development methodology of ynamines was also applied in the synthesis of enynamines, multi-coupled bis-ynamines, tris-ynamines, and the natural product peyonine, demonstrating its broad synthetic scope and applications.