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1975-51-5 Usage

Uses

2-Methyl-4-nitrobenzoic acid is used as a reagent to synthesize amino-1H-pyrazole amide derivatives, compounds that act as Raf kinase inhibitors in melanoma cells. 2-Methyl-4-nitrobenzoic acid is also used as a reagent to synthesize fluorogenic substrates, compounds that can be used for activity imaging within living cells.

Check Digit Verification of cas no

The CAS Registry Mumber 1975-51-5 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 1,9,7 and 5 respectively; the second part has 2 digits, 5 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 1975-51:
(6*1)+(5*9)+(4*7)+(3*5)+(2*5)+(1*1)=105
105 % 10 = 5
So 1975-51-5 is a valid CAS Registry Number.
InChI:InChI=1/C8H7NO4/c1-5-4-6(9(12)13)2-3-7(5)8(10)11/h2-4H,1H3,(H,10,11)

1975-51-5 Well-known Company Product Price

  • Brand
  • (Code)Product description
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  • Detail
  • Alfa Aesar

  • (H31332)  2-Methyl-4-nitrobenzoic acid, 97%   

  • 1975-51-5

  • 1g

  • 592.0CNY

  • Detail
  • Alfa Aesar

  • (H31332)  2-Methyl-4-nitrobenzoic acid, 97%   

  • 1975-51-5

  • 5g

  • 1686.0CNY

  • Detail

1975-51-5SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 20, 2017

Revision Date: Aug 20, 2017

1.Identification

1.1 GHS Product identifier

Product name 2-Methyl-4-nitrobenzoic acid

1.2 Other means of identification

Product number -
Other names 2-Methyl-4-nitro-benzoesaeure

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:1975-51-5 SDS

1975-51-5Synthetic route

4-nitro-o-xylene
99-51-4

4-nitro-o-xylene

2-methyl-4-nitrobenzoic acid
1975-51-5

2-methyl-4-nitrobenzoic acid

Conditions
ConditionsYield
With N-hydroxyphthalimide; cobalt(II) chloride hexahydrate; nitric acid; manganese (II) acetate tetrahydrate under 760.051 Torr; for 12h; Reagent/catalyst; Concentration; Reflux;72%
With oxygen; sodium hydroxide In methanol; water at 65℃; under 13501.4 Torr; for 24h; Solvent; Temperature; Concentration; Autoclave;62%
With oxygen; sodium hydroxide In ethanol; water at 60℃; under 7500.75 - 13501.4 Torr; for 24h; Solvent; Green chemistry; chemoselective reaction;58%
With manganese(IV) oxide; nitric acid for 1h; Time;
2-methyl-4-nitro-benzoic acid amide
99584-16-4

2-methyl-4-nitro-benzoic acid amide

2-methyl-4-nitrobenzoic acid
1975-51-5

2-methyl-4-nitrobenzoic acid

Conditions
ConditionsYield
With hydrogenchloride In water for 20h; Heating / reflux;89.5%
With hydrogenchloride for 20h; Hydrolysis; Heating;88%
With sulfuric acid; sodium nitrite
2-cyano-5-nitrotoluene
89001-53-6

2-cyano-5-nitrotoluene

2-methyl-4-nitrobenzoic acid
1975-51-5

2-methyl-4-nitrobenzoic acid

Conditions
ConditionsYield
With sodium hydroxide; dihydrogen peroxide In water Heating;83%
With hydrogenchloride; acetic acid at 165℃;
With sodium hydroxide
palladium(II) dichloride bis(triphenylphosphine)

palladium(II) dichloride bis(triphenylphosphine)

2-iodo-3-nitrotoluene
6277-17-4

2-iodo-3-nitrotoluene

2-methyl-4-nitrobenzoic acid
1975-51-5

2-methyl-4-nitrobenzoic acid

Conditions
ConditionsYield
With potassium carbonate In diethyl ether; hexane; water; pyrographite; ethyl acetate; N,N-dimethyl-formamide
With potassium carbonate In diethyl ether; hexane; water; pyrographite; ethyl acetate; N,N-dimethyl-formamide
With potassium carbonate In diethyl ether; hexane; water; pyrographite; ethyl acetate; N,N-dimethyl-formamide
2-methyl-4-nitrobenzeneacetamide

2-methyl-4-nitrobenzeneacetamide

2-methyl-4-nitrobenzoic acid
1975-51-5

2-methyl-4-nitrobenzoic acid

Conditions
ConditionsYield
Stage #1: 2-methyl-4-nitrobenzeneacetamide With sodium hypochlorite; potassium permanganate at 80℃; for 0.666667h;
Stage #2: With hydrogenchloride for 2h; Temperature;
4-amino-2-methylbenzoic acid
2486-75-1

4-amino-2-methylbenzoic acid

2-methyl-4-nitrobenzoic acid
1975-51-5

2-methyl-4-nitrobenzoic acid

Conditions
ConditionsYield
With Streptomyces thioluteus para-aminobenzoate N-oxygenase
2-methyl-4-nitro-benzenamine
99-52-5

2-methyl-4-nitro-benzenamine

2-methyl-4-nitrobenzoic acid
1975-51-5

2-methyl-4-nitrobenzoic acid

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: aq. HCl; NaNO2 / 0 - 5 °C
1.2: 81 percent / KCN / ethyl acetate / 20 °C
2.1: 98 percent / 80 percent aq. H2SO4 / 1.25 h / 100 °C
3.1: 88 percent / 6 N aq. HCl / 20 h / Heating
View Scheme
Multi-step reaction with 3 steps
1.1: 1 h / 60 °C
1.2: 2 h / 60 °C
2.1: dihydrogen peroxide; sodium perborate / 2 h / 300 °C / 22502.3 Torr
2.2: 0.83 h / 70 °C
3.1: potassium permanganate; sodium hypochlorite / 0.67 h / 80 °C
3.2: 2 h
View Scheme
1-<2-methyl-4-nitro-phenyl>-propane-1,2-dione-1-oxime

1-<2-methyl-4-nitro-phenyl>-propane-1,2-dione-1-oxime

2-methyl-4-nitrobenzoic acid
1975-51-5

2-methyl-4-nitrobenzoic acid

Conditions
ConditionsYield
With hydrogenchloride; sulfuric acid at 120℃;
toluene
108-88-3

toluene

2-methyl-4-nitrobenzoic acid
1975-51-5

2-methyl-4-nitrobenzoic acid

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: nitric acid; sulfuric acid / toluene / 1.25 h / 20 - 65 °C
2.1: tin(ll) chloride; iron; acetic acid / 0.5 h / 85 °C
2.2: 0.83 h
3.1: 1 h / 60 °C
3.2: 2 h / 60 °C
4.1: dihydrogen peroxide; sodium perborate / 2 h / 300 °C / 22502.3 Torr
4.2: 0.83 h / 70 °C
5.1: potassium permanganate; sodium hypochlorite / 0.67 h / 80 °C
5.2: 2 h
View Scheme
2-methyl-4-nitrobenzylpyridinium bromide
22162-16-9

2-methyl-4-nitrobenzylpyridinium bromide

2-methyl-4-nitrobenzoic acid
1975-51-5

2-methyl-4-nitrobenzoic acid

Conditions
ConditionsYield
With sodium hydroxide; bromine
asymm. nitro-o-xylene

asymm. nitro-o-xylene

A

2-methyl-4-nitrobenzoic acid
1975-51-5

2-methyl-4-nitrobenzoic acid

B

5-nitro-o-toluic acid
1975-52-6

5-nitro-o-toluic acid

Conditions
ConditionsYield
With water; nitric acid
With nitric acid
2,5-dinitrotoluene
619-15-8

2,5-dinitrotoluene

2-methyl-4-nitrobenzoic acid
1975-51-5

2-methyl-4-nitrobenzoic acid

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: tin(ll) chloride; iron; acetic acid / 0.5 h / 85 °C
1.2: 0.83 h
2.1: 1 h / 60 °C
2.2: 2 h / 60 °C
3.1: dihydrogen peroxide; sodium perborate / 2 h / 300 °C / 22502.3 Torr
3.2: 0.83 h / 70 °C
4.1: potassium permanganate; sodium hypochlorite / 0.67 h / 80 °C
4.2: 2 h
View Scheme
4-nitro-o-xylene
99-51-4

4-nitro-o-xylene

nitric acid
7697-37-2

nitric acid

A

2-methyl-4-nitrobenzoic acid
1975-51-5

2-methyl-4-nitrobenzoic acid

B

5-nitro-o-toluic acid
1975-52-6

5-nitro-o-toluic acid

hydrogenchloride
7647-01-0

hydrogenchloride

2-cyano-5-nitrotoluene
89001-53-6

2-cyano-5-nitrotoluene

acetic acid
64-19-7

acetic acid

2-methyl-4-nitrobenzoic acid
1975-51-5

2-methyl-4-nitrobenzoic acid

methanol
67-56-1

methanol

2-methyl-4-nitrobenzoic acid
1975-51-5

2-methyl-4-nitrobenzoic acid

methyl 2-methyl-4-nitrobenzoate
62621-09-4

methyl 2-methyl-4-nitrobenzoate

Conditions
ConditionsYield
With thionyl chloride at 70℃; for 4h;100%
With thionyl chloride at 70℃; for 18h;100%
With thionyl chloride at 20℃; for 21h; Esterification;99%
2-methyl-4-nitrobenzoic acid
1975-51-5

2-methyl-4-nitrobenzoic acid

methyl iodide
74-88-4

methyl iodide

methyl 2-methyl-4-nitrobenzoate
62621-09-4

methyl 2-methyl-4-nitrobenzoate

Conditions
ConditionsYield
With potassium carbonate In N,N-dimethyl-formamide at 20℃; for 2h;100%
With potassium carbonate In N,N-dimethyl-formamide at 20℃; for 2h;98%
With potassium carbonate In N,N-dimethyl-formamide at 20℃; for 3h;89%
With potassium carbonate In N,N-dimethyl-formamide at 0 - 20℃; for 4h;
2-methyl-4-nitrobenzoic acid
1975-51-5

2-methyl-4-nitrobenzoic acid

tert-butyl alcohol
75-65-0

tert-butyl alcohol

tert-butyl 4-amino-2-methylbenzoate

tert-butyl 4-amino-2-methylbenzoate

Conditions
ConditionsYield
Stage #1: 2-methyl-4-nitrobenzoic acid; tert-butyl alcohol With pyridine; p-toluenesulfonyl chloride at 0 - 20℃;
Stage #2: With hydrogen; palladium 10% on activated carbon In ethyl acetate at 20℃; for 2h;
100%
2-methyl-4-nitrobenzoic acid
1975-51-5

2-methyl-4-nitrobenzoic acid

4-amino-2-methylbenzoic acid
2486-75-1

4-amino-2-methylbenzoic acid

Conditions
ConditionsYield
With 5%-palladium/activated carbon; hydrogen In ethanol under 12001.2 Torr; Flow reactor;98%
With hydrogenchloride; tin
With hydrogen; palladium 10% on activated carbon In methanol at 20℃; for 16h;
2-methyl-4-nitrobenzoic acid
1975-51-5

2-methyl-4-nitrobenzoic acid

(2-methyl-4-nitro-phenyl)methanol
22162-15-8

(2-methyl-4-nitro-phenyl)methanol

Conditions
ConditionsYield
With Trimethyl borate; dimethylsulfide borane complex In tetrahydrofuran at 65℃; for 2h; Inert atmosphere;98%
With Trimethyl borate; dimethylsulfide borane complex In tetrahydrofuran for 6h; Reduction; Heating;93%
With Trimethyl borate; dimethylsulfide borane complex In tetrahydrofuran Reflux;90%
2-methyl-4-nitrobenzoic acid
1975-51-5

2-methyl-4-nitrobenzoic acid

(S)-dibenzyl 2-(2-ethoxy-4-(5-((((R)-2-((R)-1-(N-hydroxyformamido)propyl)heptanamido)methyl)carbamoyl)furan-2-yl)benzamido)succinate

(S)-dibenzyl 2-(2-ethoxy-4-(5-((((R)-2-((R)-1-(N-hydroxyformamido)propyl)heptanamido)methyl)carbamoyl)furan-2-yl)benzamido)succinate

(S)-dibenzyl 2-(2-ethoxy-4-(5-((((R)-2-((R)-1-(N-((2-methyl-4-nitrobenzoyl)oxy)formamido)propyl)heptanamido)methyl)carbamoyl)furan-2-yl)benzamido)succinate

(S)-dibenzyl 2-(2-ethoxy-4-(5-((((R)-2-((R)-1-(N-((2-methyl-4-nitrobenzoyl)oxy)formamido)propyl)heptanamido)methyl)carbamoyl)furan-2-yl)benzamido)succinate

Conditions
ConditionsYield
With 4-methyl-morpholine; HATU In N,N-dimethyl-formamide; acetonitrile at 50℃; for 16h;98%
2-methyl-4-nitrobenzoic acid
1975-51-5

2-methyl-4-nitrobenzoic acid

C8H4F3NO4

C8H4F3NO4

Conditions
ConditionsYield
With hydrogen fluoride; acetic acid; sodium nitrite In dichloromethane; water at 5 - 25℃; for 1h; Reagent/catalyst; Temperature;95.8%
2-methyl-4-nitrobenzoic acid
1975-51-5

2-methyl-4-nitrobenzoic acid

1-(2,3-dichlorophenyl)piperazine
41202-77-1

1-(2,3-dichlorophenyl)piperazine

(4-(2,3-dichlorophenyl)piperazin-1-yl)(2-methyl-4-nitrophenyl)methanone

(4-(2,3-dichlorophenyl)piperazin-1-yl)(2-methyl-4-nitrophenyl)methanone

Conditions
ConditionsYield
Stage #1: 2-methyl-4-nitrobenzoic acid With N-ethyl-N,N-diisopropylamine; HATU In N,N-dimethyl-formamide at 20℃; for 0.333333h;
Stage #2: 1-(2,3-dichlorophenyl)piperazine In N,N-dimethyl-formamide at 20℃;
95%
isonipecotic acid methyl ester
2971-79-1

isonipecotic acid methyl ester

2-methyl-4-nitrobenzoic acid
1975-51-5

2-methyl-4-nitrobenzoic acid

methyl 1-(2-methyl-4-nitrobenzoyl)piperidine-4-carboxylate

methyl 1-(2-methyl-4-nitrobenzoyl)piperidine-4-carboxylate

Conditions
ConditionsYield
Stage #1: isonipecotic acid methyl ester; 2-methyl-4-nitrobenzoic acid With N-ethyl-N,N-diisopropylamine In dichloromethane at 20℃; for 0.5h; Inert atmosphere;
Stage #2: With HATU In dichloromethane for 0h; Inert atmosphere;
93.4%
Stage #1: isonipecotic acid methyl ester; 2-methyl-4-nitrobenzoic acid With N-ethyl-N,N-diisopropylamine In dichloromethane at 20℃; for 0.5h;
Stage #2: With N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate In dichloromethane
93.4%
Stage #1: isonipecotic acid methyl ester; 2-methyl-4-nitrobenzoic acid With N-ethyl-N,N-diisopropylamine In dichloromethane at 20℃; for 0.5h; Inert atmosphere;
Stage #2: With N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate In dichloromethane for 10h; Inert atmosphere;
93.4%
Stage #1: isonipecotic acid methyl ester; 2-methyl-4-nitrobenzoic acid With N-ethyl-N,N-diisopropylamine In dichloromethane at 20℃; for 0.5h;
Stage #2: With HATU In dichloromethane for 10h;
93.4%
Stage #1: isonipecotic acid methyl ester; 2-methyl-4-nitrobenzoic acid With N-ethyl-N,N-diisopropylamine In dichloromethane at 20℃; for 0.5h;
Stage #2: With HATU In dichloromethane for 10h;
93.4%
2-methyl-4-nitrobenzoic acid
1975-51-5

2-methyl-4-nitrobenzoic acid

(E)-2-hydroxy-1-(methyl(oxo)(phenyl)-λ6-sulfaneylidene)guanidine

(E)-2-hydroxy-1-(methyl(oxo)(phenyl)-λ6-sulfaneylidene)guanidine

methyl((5-(2-methyl-4-nitrophenyl)-1,2,4-oxadiazol-3-yl)imino)(phenyl)-λ6-sulfanone

methyl((5-(2-methyl-4-nitrophenyl)-1,2,4-oxadiazol-3-yl)imino)(phenyl)-λ6-sulfanone

Conditions
ConditionsYield
With 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; N-ethyl-N,N-diisopropylamine In 2-methyltetrahydrofuran; ethyl acetate at 0 - 80℃; Inert atmosphere;92%
2-methyl-4-nitrobenzoic acid
1975-51-5

2-methyl-4-nitrobenzoic acid

2-methyl-4,5-dinitro-benzoic acid
101084-64-4

2-methyl-4,5-dinitro-benzoic acid

Conditions
ConditionsYield
With sulfuric acid; nitric acid89%
With sulfuric acid; nitric acid at 0 - 20℃; for 16h; Inert atmosphere;89%
With sulfuric acid; nitric acid at 0 - 20℃; for 120h;85%
ethanol
64-17-5

ethanol

2-methyl-4-nitrobenzoic acid
1975-51-5

2-methyl-4-nitrobenzoic acid

2-methyl-4-nitro-benzoic acid ethyl ester
62621-10-7

2-methyl-4-nitro-benzoic acid ethyl ester

Conditions
ConditionsYield
With sulfuric acid for 24h; Heating / reflux;82.99%
sulfuric acid Reflux;
2-methyl-4-nitrobenzoic acid
1975-51-5

2-methyl-4-nitrobenzoic acid

1-phenyl-propan-1-one
93-55-0

1-phenyl-propan-1-one

C17H15NO5

C17H15NO5

Conditions
ConditionsYield
With 2,2,6,6-tetramethyl-piperidine-N-oxyl; chloro(1,5-cyclooctadiene)rhodium(I) dimer; copper diacetate; cesium fluoride In toluene at 120℃; for 24h; Inert atmosphere;72%
2-methyl-4-nitrobenzoic acid
1975-51-5

2-methyl-4-nitrobenzoic acid

1-methyl-3-nitrobenzene
99-08-1

1-methyl-3-nitrobenzene

Conditions
ConditionsYield
With [Au(1,3-bis(2,6-diisopropylphenyl)-4,5-dihydroimidazol-2-ylidene)(O2CAd)] In toluene at 140℃; for 20h;71%
2-methyl-4-nitrobenzoic acid
1975-51-5

2-methyl-4-nitrobenzoic acid

4-amino-5-(naphthalen-1-yl-methyl)-3-mercapto-1,2,4-triazole
151297-83-5

4-amino-5-(naphthalen-1-yl-methyl)-3-mercapto-1,2,4-triazole

3-(1-naphthylmethyl)-6-(2-nitro-4-methylphenyl)-1,2,4-triazolo[3,4-b]-1,3,4-thiadiazole

3-(1-naphthylmethyl)-6-(2-nitro-4-methylphenyl)-1,2,4-triazolo[3,4-b]-1,3,4-thiadiazole

Conditions
ConditionsYield
With trichlorophosphate for 4h; Heating;65%
2-methyl-4-nitrobenzoic acid
1975-51-5

2-methyl-4-nitrobenzoic acid

4-amino-5-[4-(N,N-dimethylamino)phenyl]-3-mercapto-1,2,4-triazole
76457-90-4

4-amino-5-[4-(N,N-dimethylamino)phenyl]-3-mercapto-1,2,4-triazole

3-[4-(N,N-dimethylamino)phenyl]-6-(2-nitro-4-methylphenyl)-1,2,4-triazolo[3,4-b]-1,3,4-thiadiazole

3-[4-(N,N-dimethylamino)phenyl]-6-(2-nitro-4-methylphenyl)-1,2,4-triazolo[3,4-b]-1,3,4-thiadiazole

Conditions
ConditionsYield
With trichlorophosphate for 4h; Heating;62%
4-amino-5-[2-(N-methylamino)phenyl]-3-mercapto-1,2,4-triazole
914978-98-6

4-amino-5-[2-(N-methylamino)phenyl]-3-mercapto-1,2,4-triazole

2-methyl-4-nitrobenzoic acid
1975-51-5

2-methyl-4-nitrobenzoic acid

3-[2-(N-methylamino)phenyl]-6-(2-nitro-4-methylphenyl)-1,2,4-triazolo[3,4-b]-1,3,4-thiadiazole

3-[2-(N-methylamino)phenyl]-6-(2-nitro-4-methylphenyl)-1,2,4-triazolo[3,4-b]-1,3,4-thiadiazole

Conditions
ConditionsYield
With trichlorophosphate for 4h; Heating;60%
2-methyl-4-nitrobenzoic acid
1975-51-5

2-methyl-4-nitrobenzoic acid

2-(bromomethyl)-4-nitrobenzoic acid
37156-27-7

2-(bromomethyl)-4-nitrobenzoic acid

Conditions
ConditionsYield
With N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile) In tetrachloromethane at 80℃; for 16h;59%
Methylenbis(6-t-butyl-4-methyl-o-phenylen)hydrogenphosphit
15233-97-3

Methylenbis(6-t-butyl-4-methyl-o-phenylen)hydrogenphosphit

2-methyl-4-nitrobenzoic acid
1975-51-5

2-methyl-4-nitrobenzoic acid

C31H36NO6P

C31H36NO6P

Conditions
ConditionsYield
Stage #1: 2-methyl-4-nitrobenzoic acid With thionyl chloride; N,N-dimethyl-formamide In dichloromethane at 20℃; for 6h; Inert atmosphere;
Stage #2: Methylenbis(6-t-butyl-4-methyl-o-phenylen)hydrogenphosphit With N-ethyl-N,N-diisopropylamine In dichloromethane at 20℃; for 6h; Inert atmosphere;
55%
2-methyl-4-nitrobenzoic acid
1975-51-5

2-methyl-4-nitrobenzoic acid

tert-butyl methyl(3-(piperidine-4-carboxamido)propyl)carbamate

tert-butyl methyl(3-(piperidine-4-carboxamido)propyl)carbamate

tert-butyl methyl(3-(1-(2-methyl-4-nitrobenzoyl)piperidine-4-carboxamido)propyl)carbamate

tert-butyl methyl(3-(1-(2-methyl-4-nitrobenzoyl)piperidine-4-carboxamido)propyl)carbamate

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine; HATU In N,N-dimethyl-formamide at 20℃; for 4h; Inert atmosphere;47.16%
With N-ethyl-N,N-diisopropylamine; HATU In N,N-dimethyl-formamide at 20℃; for 4h;47.16%
With N-ethyl-N,N-diisopropylamine; HATU In N,N-dimethyl-formamide at 20℃; for 4h;47.16%
With N-ethyl-N,N-diisopropylamine; HATU In N,N-dimethyl-formamide at 20℃; for 4h;47.16%
2-methyl-4-nitrobenzoic acid
1975-51-5

2-methyl-4-nitrobenzoic acid

5-nitro-3H-isobenzofuran-1-one
67081-02-1

5-nitro-3H-isobenzofuran-1-one

Conditions
ConditionsYield
With sodium bromate; magnesium chloride In acetonitrile at 20℃; for 18h; Inert atmosphere; Irradiation; Sealed tube;38%
2-methyl-4-nitrobenzoic acid
1975-51-5

2-methyl-4-nitrobenzoic acid

2-methyl-4-nitrobenzoyl chloride
30459-70-2

2-methyl-4-nitrobenzoyl chloride

Conditions
ConditionsYield
With thionyl chloride
With thionyl chloride Heating;
With thionyl chloride Substitution;
2-methyl-4-nitrobenzoic acid
1975-51-5

2-methyl-4-nitrobenzoic acid

glycine ethyl ester hydrochloride
623-33-6

glycine ethyl ester hydrochloride

(2-Methyl-4-nitro-benzoylamino)-acetic acid ethyl ester

(2-Methyl-4-nitro-benzoylamino)-acetic acid ethyl ester

Conditions
ConditionsYield
With 1,1'-carbonyldiimidazole 1) DMF, 0 deg C -> room temperature, 20 min, 2) DMF, room temperature, 30 min; Yield given. Multistep reaction;

1975-51-5Relevant articles and documents

Oxidation of 4-nitro-o-xylene with nitric acid using N-hydroxyphthalimide under phase transfer conditions

Wei, Song-Bo,Tang, Bo,Peng, Xin-Hua

, p. 580 - 585 (2015)

4-Nitro-o-xylene was selectively oxidized to 2-methyl-4-nitrobenzoic acid using dilute nitric acid as the oxidizing agent under atmospheric pressure. The oxidation of 4-nitro-o-xylene was effectively promoted by an addition of radical initiators. Under re

Metal-Free Aerobic Oxidation of Nitro-Substituted Alkylarenes to Carboxylic Acids or Benzyl Alcohols Promoted by NaOH

Fang, Kun,Li, Guijie,She, Yuanbin

, p. 8092 - 8103 (2018/06/25)

Efficient and selective aerobic oxidation of nitro-substituted alkylarenes to functional compounds is a fundamental process that remains a challenge. Here, we report a metal-free, efficient, and practical approach for the direct and selective aerobic oxidation of nitro-substituted alkylarenes to carboxylic acids or benzyl alcohols. This sustainable system uses O2 as clean oxidant in a cheap and green NaOH/EtOH mixture. The position and type of substituent critically affect the products. In addition, this sustainable protocol enabled gram-scale preparation of carboxylic acid and benzyl alcohol derivatives with high chemoselectivities. Finally, the reactions can be conducted in a pressure reactor, which can conserve oxygen and prevent solvent loss. The approach was conducive to environmental protection and potential industrial application.

Method for synthesis of 2-aldehyde-4-aminobenzoic acid

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Paragraph 0006, (2017/04/03)

The invention relates to a method for synthesis of 2-aldehyde-4-aminobenzoic acid. The method for synthesis of 2-aldehyde-4-aminobenzoic acid, which is provided by the invention, is simple and cheap, gentle in reaction condition in the preparation process, and high in yield.

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