19780-79-1Relevant articles and documents
NOVEL AMPHIPHILIC COMPOUND HAVING DENDRONIC HYDROPHOBIC GROUP AND APPLICATION THEREOF
-
Paragraph 0104; 0110; 0111; 0117; 0118, (2020/08/20)
The present invention relates to an amphiphilic compound having a dendronic hydrophobic group, a method for preparing the same, and a method for extraction, solubilization, stabilization, or crystallization of a membrane protein by using the same. The use of the compound according to the present invention leads to an excellent membrane protein solubilization effect and a stable storage of a membrane protein in an aqueous solution for a long time, and thus can be utilized for functional analysis and structural analysis of the membrane protein. Especially, the amphiphilic compound having a dendronic hydrophobic group showed very remarkable characteristics in the visualization of protein composites through an electronic microscope. The membrane protein structural and functional analysis is one of the fields of greatest interest in current biology and chemistry, and more than half of the new drugs that are currently being developed are targeted at membrane proteins, and thus the amphiphilic compound of the present invention can be applied to membrane protein structure studies closely related to the development of new drugs.
GUERBET CONDENSATION REACTION
-
Page/Page column 17-18; 30-31, (2017/07/08)
The invention relates to a process for the preparation of a Guerbet alcohol, comprising the steps of: (a) providing at least one alcohol, wherein said at least one alcohol has a carbon atom bearing at least one hydrogen atom adjacent to the hydroxyl group; (b) providing a catalyst composition, wherein said catalyst composition comprises an alkaline catalyst and a copper-nickel catalyst comprised in a hydrotalcite; (c) mixing alcohol (a) with catalyst composition (b), thereby obtaining a mixture; and, (d) heating said mixture; thereby obtaining a Guerbet alcohol.
Functional group tolerance in organocatalytic regioselective acylation of carbohydrates
Ueda, Yoshihiro,Muramatsu, Wataru,Mishiro, Kenji,Furuta, Takumi,Kawabata, Takeo
, p. 8802 - 8805 (2015/05/06)
(Chemical Equation Presented) Organocatalytic regioselective acylation of mono- and disaccaharides with various functionalized acid anhydrides has been developed. Acylation of octyl β-D-glucopyranoside with acid anhydrides derived from R-amino acids, cinnamic acid, and gallic acid took place at C(4)-OH with 67-94% regioselectivity in the presence of catalyst 1. Regioselective acylation of disaccharides with functionalized acid anhydrides was also achieved with 78-94% selectivity. Especially, a disaccharide with seven free hydroxy groups (X = OH, R′ = H) underwent acylation at C(4)-OH with 78% regioselectivity in the presence of 1. Thus, functional group tolerance in the regioselective acylation catalyzed by 1 was found to be high.