19805-75-5Relevant articles and documents
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Chan,Bruice
, p. 7287 (1977)
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New 18F-labeled dienophiles and 18F-labeling method using IeDDA reaction with tetrazines
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Paragraph 0256; 0257; 0262-0265, (2020/11/14)
The present invention relates to a method of labeling of F-18 radioisotopes using an inverse electron demand Diels-Alder (IeDDA) reaction between a tetrazine compound and a dienophile. A ketone compound according to the present invention easily forms an enamine with a secondary amine in an aqueous solution phase to cause significantly rapid conjugation with a tetrazine compound. Particularly, as the amount of water is increased in the aqueous solution, the reaction proceeds well, so that the compound may be suitable for a bioactive compound, such as a peptide or antibody. Unlike conventional reactions producing different stereoisomers, the reaction produces a small amount of only one type of stereoisomer, besides a main product, and the product can be purified through high performance liquid chromatography, etc. Further, as compared to the conventional ^18F-labeled tetrazine or ^18F-labeled TCO synthesis with a low yield, the ^18F-labeled ketone compound represented by the following chemical formula 1 can be obtained with a high ^18F-labeling yield from a precursor thereof.COPYRIGHT KIPO 2021
METAL AMIDES OF CYCLIC AMINES
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Paragraph 0058; 0064; 0065, (2015/02/19)
Compounds, and oligomers of the compounds, are synthesized with cyclic amine ligands attached to a metal atom. These compounds are useful for the synthesis of materials containing metals. Examples include pure metals, metal alloys, metal oxides, metal nitrides, metal phosphides, metal sulfides, metal selenides, metal tellurides, metal borides, metal carbides, metal silicides and metal germanides. Techniques for materials synthesis include vapor deposition (chemical vapor deposition and atomic layer deposition), liquid solution methods (sol-gel and precipitation) and solid-state pyrolysis. Suitable applications include electrical interconnects in microelectronics and magnetoresistant layers in magnetic information storage devices. The films have very uniform thickness and high step coverage in narrow holes.
First synthesis of novel spin-labeled derivatives of camptothecin as potential antineoplastic agents
Liu, Ying-Qian,Tian, Xuan,Yang, Liu,Zhan, Zong-Cheng
scheme or table, p. 2610 - 2614 (2009/04/11)
In an effort to improve the stability of labile lactone ring and water solubility of camptothecin, five novel spin-labeled camptothecin derivatives were synthesized in quantitative yield by a simple modification of the carbodiimide method using the combination of scandium triflate (Sc(OTf)3) and 4-dimethylaminopyridine (DMAP), and the in vitro pharmacokinetic determination of the lactones of representative compound 13a showed that the biological life span of their lactone forms in human and mouse plasma significantly increased when compared with their mother compound camptothecin. Also, the in vitro cytotoxicity of compounds 13a-13e against human bladder cancer T-24 showed either similar or better activity than that of the parent drug, camptothecin, and clinically available drug, irinotecan.
