19832-98-5Relevant articles and documents
Silver-catalyzed decarboxylative C–H functionalization of cyclic aldimines with aliphatic carboxylic acids
Wang, Jingjing,Liu, Xue,Wu, Ziyan,Li, Feng,Qin, Tingting,Zhang, Siyuan,Kong, Weiguang,Liu, Lantao
, p. 2777 - 2781 (2021)
Silver-catalyzed decarboxylative C–H alkylation of cyclic aldimines with abundant aliphatic carboxylic acids has been realized under mild reaction conditions generating the corresponding products in moderate to good yields (32%–91%). In addition, a gram-scale reaction, late-stage modification of drug, synthetic transformation of the product, and further application of the catalytic strategy were also performed. Preliminary studies indicate that the reaction undergoes a radical process.
Silver-Catalyzed Decarboxylative Trifluoromethylation of Aliphatic Carboxylic Acids
Tan, Xinqiang,Liu, Zhonglin,Shen, Haigen,Zhang, Pei,Zhang, Zhenzhen,Li, Chaozhong
supporting information, p. 12430 - 12433 (2017/09/25)
The silver-catalyzed decarboxylative trifluoromethylation of aliphatic carboxylic acids is described. With AgNO3 as the catalyst and K2S2O8 as the oxidant, the reactions of aliphatic carboxylic acids with (bpy)C
Silver-Catalyzed Radical Transformation of Aliphatic Carboxylic Acids to Oxime Ethers
Zhu, Yuchao,Wen, Xiaojin,Song, Song,Jiao, Ning
, p. 6465 - 6472 (2016/10/14)
Oximes and oxime ethers are privileged building blocks and can be conveniently converted to ketones, amines, hydroxylamines, and nitriles. We describe the catalytic decarboxylation of aliphatic carboxylic acids to oxime ethers. With AgNO3 as the catalyst, valuable oxime ethers bearing various substituents could be easily obtained. The broad substrate scope, easy accessibility of aliphatic carboxylic acids, and mild reaction conditions make this strategy immediately applicable to the synthesis, late-stage functionalization, and modification of biologically active compounds. Experimental studies show the reaction undergoes a radical process.
