19853-01-1Relevant articles and documents
Synthesis, antimicrobial activity, and molecular docking study of fluorine-substituted indole-based imidazolines
Mendoza-Figueroa, Humberto L.,Serrano-Alva, Maria Trinidad,Aparicio-Ozores, Gerardo,Martínez-Gudi?o, Gelacio,Suárez-Castillo, Oscar R.,Pérez-Rojas, Nadia A.,Morales-Ríos, Martha S.
, p. 1624 - 1633 (2018)
A series of 2- or 3-(4,5-dihydro-1H-imidazol-2-yl)-1H-indole derivatives were synthesized, characterized, and evaluated for their in vitro antibacterial and antifungal activities. Additionally, the synthesized compounds were docked into the II DNA gyrase B active site, and their predicted binding modes were inspected. Inhibitory activity were tested against two species of Gram-negative bacteria (Escherichia coli, Pseudomonas aeruginosa), two species of Gram-positive bacteria (Staphylococcus aureus, Listeria monocytogenes) and two fungi (Candida albicans, Aspergillus niger) using the broth microdilution method. The fluorine-substituted 2-(2-imidazolyl)indole 2b was found to be the most potent antibacterial compound against E. coli and S. aureus strains (MIC value 80 μg/mL). Compounds showed better activity against Gram-positive bacteria compared to Gram-negative bacteria. The docking results predicted that the imidazoline-indole hybrid moiety bind to the active site protein ATP-binding pocket from E. coli and S. aureus with good interaction energy scores. The significant loss of antibacterial activity for some imidazoline-indole analogs could be attributed to several nonoptimal enzyme interactions, including poor hydrogen bonds provided by Asp73 (E. coli gyrase numbering) or Asp81 (S. aureus gyrase numbering) and an associated water molecule.
SYNTHESIS AND PROPERTIES OF AZOLES AND THEIR DERIVATIVES. 32. SYNTHESIS AND SOME TRANSFORMATIONS OF HYDROCHLORIDES OF IMIDO ESTERS OF INDOLECARBOXYLIC ACIDS
Kelarev, V. I.,Shvekhgeimer, G. A.
, p. 501 - 506 (2007/10/02)
The Pinner reaction with the nitriles of indole-3-carboxylic and 3-indolylacetic acids was studied.The hydrochlorides of the imide esters of these acids, which were converted to the free bases, amides, and esters, were synthesized.Imidazolines, benzimidazoles, and benzoxazoles that contain indole substituents were obtained by condensation of the hydrochlorides of the imido esters of the indolecarboxylic acids with ethylenediamine, o-phenylenediamine, and o-aminophenol.
