1995-76-2Relevant articles and documents
Synthesis of α-CF3 and α-CF2H amines: Via the aminofluorination of fluorinated alkenes
Yang, Ling,Fan, Wen-Xin,Lin,Tan, Dong-Hang,Li, Qingjiang,Wang, Honggen
, p. 5907 - 5910 (2018)
A novel synthesis of α-CF3 and α-CF2H amines via the aminofluorination of gem-difluoroalkenes and mono-fluoroalkenes, respectively, is reported. The method employs Selectfluor as an electrophilic fluorine source and acetonitrile as a nitrogen source. Mechanistic studies revealed a single-electron oxidation/fluorine-abstraction/Ritter-type amination pathway. The protocol allowed the synthesis of a broad range of fluorinated amines including those bearing quaternary carbon centers with good efficiency and functional group tolerance.