19959-81-0Relevant articles and documents
Multiple biological activities and molecular docking studies of newly synthesized 3-(pyridin-4-yl)-1H-pyrazole-5-carboxamide chalcone hybrids
Sribalan, Rajendran,Banuppriya, Govindharasu,Kirubavathi, Maruthan,Jayachitra,Padmini, Vediappen
, p. 5624 - 5630 (2016)
A series of fifteen new chemical entities, 3-(pyridin-4-yl)-1H-pyrazole-5-carboxamide chalcones (6a–o), were synthesized as new hybrids with enriched biological activities compared to their parent molecules. The compounds were characterized by1H NMR,13C NMR, Mass and IR spectral studies. Their antibacterial, anti-inflammatory and antioxidant activities have been evaluated. These compounds showed moderate to good antibacterial, anti-inflammatory and antioxidant activities. The molecular docking analysis was performed with cyclooxygenase enzyme to ascertain the probable binding model.
A novel pyridine-pyrazole based selective “turn-off” fluorescent chemosensor for Fe(III) ions
Madhu,Sivakumar
, p. 341 - 348 (2018/12/05)
A novel pyridine-pyrazole based “turn-off” fluorescent chemosensor namely, 5-N-(pyridine-2-yl)-3-(pyridine-4-yl)-1H-pyrazole-5-carboxamide (PPPC) was designed, synthesized and well characterized by NMR, ESI-MS and FT-IR spectroscopic techniques. UV–vis absorption and fluorescence spectroscopic studies show that PPPC exhibits high selectivity and sensitivity towards Fe3+ ion in DMSO/H2O solution (9:1, v/v) over other metal ions. The binding constant (K) of PPPC with Fe3+ was calculated to be 5.1 × 10?2 M and 6.1 × 10?2 M from Benesi-Hildebrand plot using UV–vis and fluorescence spectrophotometer respectively. The detection limit of PPPC for Fe3+ was further determined as 57 nM and 88 nM by UV–vis and fluorescence titrations. Moreover, the binding mechanism of Fe3+ with PPPC was confirmed by DFT study.
MODULATORS OF OCULAR OXIDATIVE STRESS
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Page/Page column 27; 43, (2009/07/03)
Described herein are compounds, compositions and methods directed to the treatment of ophthalmic conditions characterized by oxidative stress or damage in a subject by reducing the reactive oxygen species in the subject. Also described herein are methods for reducing ophthalmic photooxidative damage in a subject.
