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199666-03-0

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199666-03-0 Usage

Uses

Ro 61-8048 is a potent and competitive kynurenine 3-monooxygenase (KMO) inhibitor.

Biological Activity

Potent and competitive kynurenine 3-hydroxylase inhibitor (K i = 4.8 nM, IC 50 = 37 nM). Increases kynurenic acid levels to concentrations that antagonize the glycine site of NMDA receptors. Brain penetrant and exhibits antidystonic, anticonvulsant and neuroprotective activities.

Biochem/physiol Actions

Ro 61-8048 is an inhibitor of kynurenine 3-monooxygenase (KMO) that increases kynurenic acid levels and reduces extracellular glutamate in the brain.

Check Digit Verification of cas no

The CAS Registry Mumber 199666-03-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,9,9,6,6 and 6 respectively; the second part has 2 digits, 0 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 199666-03:
(8*1)+(7*9)+(6*9)+(5*6)+(4*6)+(3*6)+(2*0)+(1*3)=200
200 % 10 = 0
So 199666-03-0 is a valid CAS Registry Number.
InChI:InChI=1/C17H15N3O6S2/c1-25-15-7-6-13(9-16(15)26-2)28(23,24)19-17-18-14(10-27-17)11-4-3-5-12(8-11)20(21)22/h3-10H,1-2H3,(H,18,19)

199666-03-0 Well-known Company Product Price

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  • Sigma

  • (SML0233)  Ro 61-8048  ≥98% (HPLC)

  • 199666-03-0

  • SML0233-5MG

  • 1,077.57CNY

  • Detail
  • Sigma

  • (SML0233)  Ro 61-8048  ≥98% (HPLC)

  • 199666-03-0

  • SML0233-25MG

  • 4,351.23CNY

  • Detail

199666-03-0SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 17, 2017

Revision Date: Aug 17, 2017

1.Identification

1.1 GHS Product identifier

Product name 3,4-dimethoxy-N-[4-(3-nitrophenyl)-1,3-thiazol-2-yl]benzenesulfonamide

1.2 Other means of identification

Product number -
Other names Ro 61-8048

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:199666-03-0 SDS

199666-03-0Downstream Products

199666-03-0Relevant articles and documents

SMALL MOLECULE INHIBITORS OF KYNURENINE-3-MONOOXYGENASE

-

Page/Page column 59, (2008/06/13)

The present invention relates to compounds of formula (Ia) or (Ib) and their tautomers and/or pharmaceutically acceptable salts and compositions and methods of uses thereof.

Synthesis and biochemical evaluation of N-(4-phenylthiazol-2- yl)benzenesulfonamides as high-affinity inhibitors of kynurenine 3- hydroxylase

R?ver, Stephan,Cesura, Andrea M.,Huguenin, Philipp,Kettler, Rolf,Szente, Andre

, p. 4378 - 4385 (2007/10/03)

In this paper we describe the synthesis, structure-activity relationship (SAR), and biochemical characterization of N-(4-phenylthiazol-2- yl)benzenesulfonamides as inhibitors of kynurenine 3-hydroxylase. The compounds 3,4-dimethoxy-N-[4-(3-nitrophenyl)thi

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