19978-61-1Relevant articles and documents
Structurally different mono-, bi- and trinuclear Pd(II) complexes and their DNA/protein interaction, DNA cleavage, and anti-oxidant, anti-microbial and cytotoxic studies
Shanmugapriya,Jain, Ruchi,Sabarinathan,Kalaiarasi,Dallemer,Prabhakaran
, p. 10324 - 10338 (2017)
A series of new structurally different Pd(ii) complexes was obtained by the reactions between K2[PdCl4], 3-methoxysalicylaldehyde-4(N)-substituted thiosemicarbazone [H2L1-H2L4] and bis(diphenylphosphino)ethane [dppe]. All the complexes were characterized by using various spectral techniques (IR, electronic, 1H-NMR and mass spectroscopy). The crystal structures of complexes 1, 3, 4 and 3a & 4a were determined using X-ray crystallographic technique. The interactions of the new complexes with calf thymus DNA (CT-DNA) and bovine serum albumin (BSA) were evaluated using various spectroscopic methods, which showed the interaction potential of the complexes with CT-DNA and BSA. Further, they cleaved supercoiled DNA pBR322. The anti-oxidant profiles of the complexes were found to be better than the standards against 2,2′-diphenyl-1-picrylhydrazyl radicals (DPPH) and superoxide anion radicals. The antibacterial activity of the complexes against five pathogenic bacteria such as Staphylococcus aureus, Salmonella typhi, Escherichia coli, Bacillus subtilis and Pseudomonas aeruginosa was found to be better than their parent ligands. The complexes exhibited potential cytotoxicity against human breast cancer cells (MCF-7) in the following order: 4 > 3 > 1 > cisplatin > 2.
PREPARATION AND REACTIONS OF HYDROXO-ENYLPALLADIUM(II) DERIVATIVES
Rotondo, Enrico,Priolo, Francesca Cusmano,Donato, Andrea,Pietropaolo, Rosario
, p. 273 - 280 (1983)
Some new hydroxo-enyl derivatives of palladium(II) of the type 2, and PF6 (C7H8 = norbornadiene, diene = norbornadiene or 1,5-cyclooctadiene; L-L = 2,2'-dipyridyl or 1,10-phenanthroline) have been made by nucleophilic attack of H2O on the diene coordinated to the metal in dispositively charged complexes.Evidence is presented to show that the hydroxonorbornenyl-1,2-bis(diphenylphosphino)ethane palladium(II) is involved as an intermediate, in an unusual example of oxidation of the alcoholic group through a palladium(II)-mediated intramolecular hydrogen transfer.
Meso -Tetra-(4-pyridyl)porphyrin/palladium(ii) complexes as anticancer agents
Alves, Kamilla M.,Ayalla, Alejando P.,Batista, Alzir A.,Dutra, Jocely De L.,Ellena, Javier,Gon?alves, Pablo J.,Guedes, Adriana P. M.,Honorato, Jo?o,Li?o, Luciano M.,Velozo-Sa, Vivianne S.
, p. 16254 - 16264 (2021/11/27)
This study reports the synthesis, structural characterization and cytotoxic activity of four new palladium/pyridylporphyrin complexes, with the general formula {TPyP[PdCl(P-P)]4}(PF6)4, where P-P is 1,2-bis(diphenylphosphino)ethane (dppe), 1,3-bis(diphenylphosphino)propane (dppp), 1,2-bis(diphenylphosphino)butane (dppb) or 1,1′-bis(diphenylphosphino)ferrocene (dppf). The complexes were characterized by elemental analysis, and by FT-IR, UV/Vis, 1H and 31P{1H} NMR (1D/2D) spectroscopy. The slow evaporation of a methanolic solution of {TPyP[PdCl(dppb)]4}(PF6)4 (in an excess of NaBF4 salt) resulted in single crystals suitable for X ray diffraction, allowing the determination of the tridimensional structure of this complex, which crystallized in the P21/a space group. The cytotoxicity of the complexes against MDA-MB-231 (breast cancer cells) and MCF-10A (non-tumor breast cancer cells), was determined by the colorimetric MTT method, which revealed that all four complexes show selective indexes close to 1.2, lower than that of cisplatin for the same cells (12.12). The interaction of the complexes with CT-DNA was evaluated by UV-visible and viscosity measurements and it was determined that the complexes interact moderately with CT-DNA, probably by H-bonding/π-π stacking and electrostatic interactions. This journal is
Pyrrole thioamide complexes of the d8 metals platinum(II), palladium(II) and gold(III)
Tang, Haiming,Saunders, Graham C.,Ma, Xiaochuan,Henderson, William
, (2019/12/09)
Reactions of the cycloaurated gold(III) complexes [AuCl2(2-benzylpyridyl)] and [AuCl2(C6H4CH2NMe2)] with a set of pyrrole-2-thioamide ligands, containing various substituents on the pyrrole ring, gave a series of new gold(III) pyrrole thioamide complexes. X-ray crystal structures on two complexes indicate that the pyrrole thioamide ligand is coordinated through the deprotonated pyrrole nitrogen, as well as the sulfur atom of the deprotonated thioamide group, forming five-membered chelate ring complexes. In both complexes, the two highest trans-influence donor atoms (C and S) are mutually cis. Related sets of platinum(II) and palladium(II) pyrrole thioamide complexes were similarly prepared by reactions of cis-[PtCl2(PPh3)2] and [PdCl2(dppe)] (dppe = Ph2PCH2CH2PPh2)] respectively. The complexes were characterised by NMR and IR spectroscopies, and ESI mass spectrometry. A preliminary investigation of the activity of a selection of compounds towards A549 (adenocarcinomic human alveolar basal epithelial) cells was also carried out.
Triphenylene based metal-pyridine cages
Berton, Giacomo,Lorenzetto, Tommaso,Borsato, Giuseppe,Sgarbossa, Paolo,Santo, Claudio,Visentin, Fabiano,Fabris, Fabrizio,Scarso, Alessandro
supporting information, (2019/10/02)
C3-symmetric pyridine containing tris-benzyl-O-substituted hexahydroxytriphenylene derivatives were prepared and used in combination with square-planar Pd(II) and Pt(II) complexes for the self-assembly of molecular cages in solution. The formation of a trigonal bipyramid M3L2 cage was demonstrated by multinuclear NMR analyses and pseudo 2D DOSY experiments and supported by semi-empirical calculations.
