19980-19-9Relevant articles and documents
Easy preparation of enoxysilanes from aldehydes and ketones catalyzed by samarium diiodide
Hydrio, Jerome,Van De Weghe, Pierre,Collin, Jacqueline
, p. 68 - 72 (1997)
Ketones and α-substituted aldehydes are converted to trimethylsilyl enol ethers by reaction with the trimethylsilyl ketene acetal of methyl isobutyrate in dichloromethane in presence of a catalytic amount of samarium diiodide.
Halogenative difluorohomologation of ketones
Fedorov, Oleg V.,Kosobokov, Mikhail D.,Levin, Vitalij V.,Struchkova, Marina I.,Dilman, Alexander D.
, p. 5870 - 5876 (2015/06/16)
A method for the difluorohomologation of ketones accompanied by halogenation of a C-H bond is described. The reaction involves silylation, difluorocarbene addition using Me3SiCF2Br activated by a bromide ion, and halogenation of intermediate cyclopropanes with N-bromo- or N-iodosuccinimide. The whole process is performed without isolation of intermediates. The resulting α,α-difluoro-β-halo-substituted ketones can be readily converted into fluorine containing pyrazole derivatives and oxetanes.
Enantioselective desymmetrization of prochiral ketones via an organocatalytic deprotonation process
Claraz, Aurelie,Oudeyer, Sylvain,Levacher, Vincent
, p. 764 - 768 (2013/07/25)
The first desymmetrization of 4-substituted cyclohexanones by organocatalytic asymmetric deprotonation at low catalyst loading is reported. The combination of N,O-bis(trimethylsilyl)acetamide (BSA) and chiral quaternary ammonium aryloxide salts has been u
