19989-64-1Relevant articles and documents
Generation of a thiazole o-quinodimethane from an imino derivative and its intermolecular Diels-Alder trapping with alkynes or quinones
Jouve, Karine,Pautet, Felix,Domard, Monique,Fillion, Houda
, p. 1064 - 1067 (1999)
(E)-5-(N-Benzylformimidoyl)-4-methylthiazole 3 was prepared in good yield from 5-formyl-4-methylthiazole and benzylamine. Treatment of 3 with methylchloroformate in the presence of ethyldiisopropylamine in refluxing toluene has generated o-quinodimethane
Deaminizing method for amidogen-containing aromatic compounds
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Paragraph 0021, (2016/10/09)
The invention relates to the technical field of organic synthesis, and provides a deaminizing method for amidogen-containing aromatic compounds. The deaminizing method aims at solving the problems that as for a deaminizing method commonly used at present, as strong acid is used, the environment is polluted, the reaction temperature needs to be accurately controlled and production is not facilitated. The deaminizing method for the amidogen-containing aromatic compounds includes the steps that the amidogen-containing aromatic compounds, nitrite and solvents are mixed to be put into a pressure-proof tube, a stirring reaction is carried out for 12 hours to 72 hours at the temperature of 80 DEG C to 130 DEG C, and the deaminized-amidogen aromatic compounds are separated and obtained. The deaminizing method is efficient, easy and convenient to operate and free of waste acid pollution.
Pyrrole derivatives
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, (2008/06/13)
Pyrrole derivatives represented by the following formula: wherein Ring Z is an optionally substituted pyrrole ring, etc.; W2 is —CO—, —SO2—, an optionally substituted C1-C4 alkylene, etc.; Ar2 is an optionally substituted aryl, etc.; W2 and Ar1 mean the following (1) and (2): (1) W1 is an optionally substituted C1-C4 alkylene, etc.; Ar1 is an optionally substituted bicyclic heteroaryl having 1 to 4 nitrogen atoms as ring-forming atoms: (2) W1 is an optionally substituted C2-C5 alkylene, an optionally substituted C2-C5 alkenylene, etc.; and Ar1 is an aryl or monocyclic heteroaryl, which are substituted by carboxyl, an alkoxycarbonyl, etc. at the ortho- or meta-position thereof with respect to the binding position of W1, or a pharmaceutically acceptable salt thereof These compounds are useful as medicaments such as a fibrosis inhibitor for organs or tissues.
