29958-83-6Relevant articles and documents
Synthesis of novel histamine H4 receptor antagonists
Lane, Charlotte A.L.,Hay, Duncan,Mowbray, Charles E.,Paradowski, Michael,Selby, Matthew D.,Swain, Nigel A.,Williams, David H.
, p. 1156 - 1159 (2012/03/11)
This letter describes the discovery and synthesis of a series of octahydropyrrolo[3,4-c]pyrrole based selective histamine hH4 receptor antagonists. The amidine compound 20 was found to be a potent and selective histamine H4 receptor antagonist with moderate clearance and a high volume of distribution.