399044-23-6Relevant articles and documents
A convenient entry to indolizidine alkaloids using Kharasch type reactions
Morales-Chamorro, Maricela,Meza-González, Jorge,Cordero-Vargas, Alejandro
supporting information, p. 4892 - 4894 (2015/07/28)
A convenient entry to indolizidine alkaloids based on a free-radical atom transfer reaction (ATRA or Kharasch reaction) as the key step is reported. The strategy is based on the free radical reaction between ethyl iodoacetate and an l-proline derivative serving as a radical acceptor. The key intermediate obtained after the radical reaction is used for the synthesis of indolizidine (-)-167B and of an advanced intermediate for the synthesis of (+)-dendroprimine.