3999-05-1Relevant articles and documents
Synthesis and antibacterial activity in?vitro of 2-benzylthioimidazo[1,2-a]pyridine derivatives against pathogenic bacterial
Ablo, Evrard,Coulibali, Siomenan,Touré, Daouda,Coulibaly, Souleymane,Kablan, Ahmont Landry Claude,Konan Kouadio, Fernique,Sissouma, Drissa,Guessend Kouadio, Nathalie,Ané, Adjou
, p. 462 - 469 (2022/02/25)
To explore the antibacterial activity, a set of new 2-thiobenzyl-3-nitro-imidazo[1,2-a]pyridine derivatives were synthesized (9a–h) and characterized by NMR 1H, 13C and high-resolution mass (HRMS). These compounds were obtained by interaction between the 3-nitro-imidazo[1,2-a]pyridine isothiouronium salt (7) with benzyl chloride or bromide (8) in the presence of sodium hydroxide (NaOH). Eight (9a–h) of them were evaluated in?vitro on the positive gram bacterium (S. aureus ATCC 29213) and two others negative gram bacteria (P. aeruginosa ATCC 27853 and P. aeruginosa 933 C/21) by methods diffusion in solid medium and liquid macrodilution. Five among the eight compounds (9a, 9d, 9h, 9f and 9g) showed significant antibacterial activity on P. aeruginosa ATCC 27853 and P. aeruginosa 933 C/21with MIC between 7.81 and 250 μg/mL. All compounds were inactive on S. aureus. The compounds 9a and 9g were more potent on the two strains of P. aeruginosa ATCC 27853.
Synthesis and Physicochemical Properties of New Chalcones Containing a 2-Chloroimidazo[1,2-a]pyridine Fragment
Abashev, G. G.,Chukhlantseva, A. N.,Ermolov, D. A.,Lunegov, I. V.,Mokrushin, I. G.,Shklyaeva, E. V.
, p. 1940 - 1947 (2022/01/24)
Abstract: New chalcones containing a 2-chloroimidazo[1,2-a]pyridine fragment have been synthesized, and their optical properties have been studied. The Stokes shifts, forbidden band gap widths, molar absorption coefficients, and fluorescence quantum yields have been determined on the basis of their absorption and emission spectra. Introduction of an additional thiophene fragment into the chalcone molecules produced an increase of the Stokes shift, red shift of the emission maximum, and sharp increase of the quantum yield (up to 22%). The synthesized chalcones showed high thermal stability and good film-forming properties, and films obtained therefrom exhibited an ordered structure.
TRPC5 INHIBITORS AND METHODS OF USING SAME
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, (2019/04/10)
Provided herein are TRPC5 inhibitors and methods of using the same, e.g., to protect podocytes and/or treat kidney disease.
