69879-22-7Relevant articles and documents
Preparation method of small molecule tyrosine kinase inhibitor
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Paragraph 0098-0101, (2021/09/29)
The invention provides a preparation method of a small molecule tyrosine kinase inhibitor. , The compound II is subjected to a condensation reaction with the compound I, and then the ester is reduced to an aldehyde using a reducing agent, and the compound V product and the condensation reaction are reacted to obtain a compound. The preparation method disclosed by the invention is easy to obtain. The method has the advantages of mild reaction, environment friendliness, suitability for industrial production and certain safety.
CRYSTAL FORM, SALT TYPE OF SUBSTITUTED 2-HYDRO-PYRAZOLE DERIVATIVE AND PREPARATION METHOD THEREFOR
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, (2019/07/10)
A crystal form and a salt type of a substituted 2-hydro-pyrazole derivative, preparation method therefor, and use of the crystal form and the salt type in preparation of a medicament for treating cancers such as breast cancer, lung cancer and the like.
AMINOPYRIDINE COMPOUNDS AND METHODS FOR THE PREPARATION AND USE THEREOF
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Paragraph 0458; 0489, (2018/12/02)
The present invention relates generally to therapeutics targeting the bacterium Porphyromonas gingivalis, including its proteases arginine gingipain A/B (Rgp), and their use for the treatment of disorders associated with P. gingivalis infection, including brain disorders such as Alzheimer's disease. In certain embodiments, the invention provides compounds according to Formula I and Formula III, as described herein, and pharmaceutically acceptable salts thereof.
