87-69-4 Usage
Chemical Properties
Different sources of media describe the Chemical Properties of 87-69-4 differently. You can refer to the following data:
1. white crystals
2. Tartaric acid occurs as colorless monoclinic crystals, or a white or
almost white crystalline powder. It is odorless, with an extremely
tart taste.
Uses
Different sources of media describe the Uses of 87-69-4 differently. You can refer to the following data:
1. L-(+)-Tartaric Acid is a naturally occurring chemical compound found in berries, grapes and various wines. It provides antioxidant properties and contributes to the sour taste within these products.
2. In the soft drink industry, confectionery products, bakery products, gelatin desserts, as an acidulant. In photography, tanning, ceramics, manufacture of tartrates. The common commercial esters are the diethyl and dibutyl derivatives used for lacquers and in textile printing. Pharmaceutic aid (buffering agent).
3. L-(+)-Tartaric acid is widely utilized in pharmaceutical industries. It is used in soft drinks, confectionaries, food products, gelatin desserts and as a buffering agent. It forms a compound, TiCl2(O-i-Pr)2 with Diels-Alder catalyst and acta as a chelate agent in metal industries. Owing to its efficient chelating property towards metal ions, it is used in farming and metal industries for complexing micronutrients and for cleaning metal surfaces, respectively.
Definition
ChEBI: A tetraric acid that is butanedioic acid substituted by hydroxy groups at positions 2 and 3.
Production Methods
Tartaric acid occurs naturally in many fruits as the free acid or in
combination with calcium, magnesium, and potassium.
Commercially, L-(＋)-tartaric acid is manufactured from potassium
tartrate (cream of tartar), a by-product of wine making.
Potassium tartrate is treated with hydrochloric acid, followed by the
addition of a calcium salt to produce insoluble calcium tartrate.
This precipitate is then removed by filtration and reacted with 70%
sulfuric acid to yield tartaric acid and calcium sulfate.
General Description
Tartaric Acid belongs to the group of carboxylic acids, and is abundantly found in grapes and wine. It is widely used in drugs, food, and beverage industry.
Flammability and Explosibility
Notclassified
Pharmaceutical Applications
Tartaric acid is used in beverages, confectionery, food products, and
pharmaceutical formulations as an acidulant. It may also be used as
a sequestering agent and as an antioxidant synergist. In pharmaceutical
formulations, it is widely used in combination with
bicarbonates, as the acid component of effervescent granules,
powders, and tablets.
Tartaric acid is also used to form molecular compounds (salts
and cocrystals) with active pharmaceutical ingredients to improve
physicochemical properties such as dissolution rate and solubility.
Biochem/physiol Actions
L-(+)-Tartaric acid serves as a donor ligand for biological processes. It is used as a food additive in candies and soft drinks to impart a sour taste.
Safety Profile
Moderately toxic by intravenous route. Mildly toxic by ingestion. Reaction with silver produces the unstable silver tartrate. When heated to decomposition it emits acrid smoke and irritating fumes.
Safety
Tartaric acid is widely used in food products and oral, topical, and
parenteral pharmaceutical formulations. It is generally regarded as
a nontoxic and nonirritant material; however, strong tartaric acid
solutions are mildly irritant and if ingested undiluted may cause
gastroenteritis.
An acceptable daily intake for L-(＋)-tartaric acid has not been set
by the WHO, although an acceptable daily intake of up to 30 mg/kg
body-weight for monosodium L-(＋)-tartrate has been established.
LD50 (mouse, IV): 0.49 g/kg
storage
The bulk material is stable and should be stored in a well-closed
container in a cool, dry place.
Incompatibilities
Tartaric acid is incompatible with silver and reacts with metal
carbonates and bicarbonates (a property exploited in effervescent
preparations).
Regulatory Status
GRAS listed. Accepted for use as a food additive in Europe.
Included in the FDA Inactive Ingredients Database (IM and IV
injections; oral solutions, syrups and tablets; sublingual tablets;
topical films; rectal and vaginal preparations). Included in
nonparenteral medicines licensed in the UK. Included in the
Canadian List of Acceptable Non-medicinal Ingredients.
Check Digit Verification of cas no
The CAS Registry Mumber 87-69-4 includes 5 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 2 digits, 8 and 7 respectively; the second part has 2 digits, 6 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 87-69:
(4*8)+(3*7)+(2*6)+(1*9)=74
74 % 10 = 4
So 87-69-4 is a valid CAS Registry Number.
InChI:InChI=1/C4H6O6/c5-1(3(7)8)2(6)4(9)10/h1-2,5-6H,(H,7,8)(H,9,10)/p-2/t1-,2+
87-69-4Relevant articles and documents
Efficient Catalysts for the Green Synthesis of Adipic Acid from Biomass
Deng, Weiping,Yan, Longfei,Wang, Binju,Zhang, Qihui,Song, Haiyan,Wang, Shanshan,Zhang, Qinghong,Wang, Ye
supporting information, p. 4712 - 4719 (2021/01/20)
Green synthesis of adipic acid from renewable biomass is a very attractive goal of sustainable chemistry. Herein, we report efficient catalysts for a two-step transformation of cellulose-derived glucose into adipic acid via glucaric acid. Carbon nanotube-supported platinum nanoparticles are found to work efficiently for the oxidation of glucose to glucaric acid. An activated carbon-supported bifunctional catalyst composed of rhenium oxide and palladium is discovered to be powerful for the removal of four hydroxyl groups in glucaric acid, affording adipic acid with a 99 % yield. Rhenium oxide functions for the deoxygenation but is less efficient for four hydroxyl group removal. The co-presence of palladium not only catalyzes the hydrogenation of olefin intermediates but also synergistically facilitates the deoxygenation. This work presents a green route for adipic acid synthesis and offers a bifunctional-catalysis strategy for efficient deoxygenation.
A cobalt-substituted Keggin-Type polyoxometalate for catalysis of oxidative aromatic cracking reactions in water
Hong, Dachao,Kitagawa, Yasutaka,Kon, Yoshihiro,Shimoyama, Yoshihiro,Tamura, Satoru
, p. 8042 - 8048 (2020/12/28)
Efficient detoxification of harmful benzene rings into useful carboxylic acids in water is indispensable for achieving a clean water environment. We report herein that oxidative aromatic cracking (OAC) reactions in water were achieved using a catalytic system with a cobalt-substituted Keggin-Type polyoxometalate (Co-POM) as a catalyst, an Oxone monopersulfate compound as a sacrificial oxidant and sodium bicarbonate as an additive under mild conditions. Sodium bicarbonate plays a crucial role in the selective OAC reactions by Co-POM using ethylbenzenesulfonate as a model substrate. The reactive species was characterized to be a cobalt(iii)-oxyl species based on 31P NMR, UV-vis spectroscopic, kinetic, and theoretical analyses. The electrophilicity of the cobalt(iii)-oxyl species was demonstrated by a linear relationship with a negative slope in the Hammett plots of initial rates obtained from the OAC reactions of m-xylenesulfonate derivatives. Besides, we have verified the degradation pathway of the OAC reactions using benzene as a model substrate in the catalytic system. The degradation was initiated by an electrophilic attack of the cobalt(iii)-oxyl species on benzene to yield phenol followed by producing catechol, muconic acid, maleic/fumaric acid, tartaric acid derivatives and formic acid on the basis of 1H NMR spectroscopic analysis.
Decorated single-enantiomer phosphoramide-based silica/magnetic nanocomposites for direct enantioseparation
Karimi Ahmadabad, Fatemeh,Pourayoubi, Mehrdad,Bakhshi, Hadi
, p. 27147 - 27156 (2019/09/12)
The nano-composites Fe3O4SiO2(-O3Si[(CH2)3NH])P(O)(NH-R(+)CH(CH3)(C6H5))2 (Fe3O4SiO2PTA(+)) and Fe3O4SiO2(-O3Si[(CH2)3NH])P(O)(NH-S(-)CH(CH3)(C6H5))2 (Fe3O4SiO2PTA(-)) were prepared and used for the chiral separation of five racemic mixtures (PTA = phosphoric triamide). The separation results show chiral recognition ability of these materials with respect to racemates belonging to different families of compounds (amine, acid, and amino-acid), which show their feasibility to be potential adsorbents in chiral separation. The nano-composites were characterized by FTIR, TEM, SEM, EDX, XRD, and VSM. The VSM curves of nano-composites indicate their superparamagnetic property, which is stable after their use in the separation process. Fe3O4, Fe3O4SiO2, Fe3O4SiO2PTA(+) and Fe3O4SiO2PTA(-) are regularly spherical with uniform shape and the average sizes of 17-20, 18-23, 36-47 and 43-52 nm, respectively.
