1000819-13-5Relevant articles and documents
Synthesis and structure-activity relationships of thieno[2,3-b]pyrroles as antagonists of the GnRH receptor
Arnould, Jean Claude,Delouvrie, Benedicte,Boutron, Pascal,Dossetter, Al G.,Foote, Kevin M.,Hamon, Annie,Hancox, Urs,Harris, Craig S.,Hutton, Mike,Lamorlette, Maryannick,Matusiak, Zbigniew
, p. 6448 - 6454 (2008/09/17)
A new class of small-molecule GnRH antagonists, the thieno[2,3-b]pyrroles, was designed. Herein, the synthesis and structure-activity relationships are described. Substitution at the C4 position was investigated; during this study, it was observed that in