1001322-87-7Relevant articles and documents
Optimization of TopoIV Potency, ADMET Properties, and hERG Inhibition of 5-Amino-1,3-dioxane-Linked Novel Bacterial Topoisomerase Inhibitors: Identification of a Lead with in Vivo Efficacy against MRSA
Chen, Anna,Cummings, Jason E.,Duncan, Leonard R.,English, Anthony,Koci, Bryan,Li, Linsen,Lindert, Steffen,Lu, Yanran,Mann, Chelsea A.,Mcelroy, Craig A.,Mitton-Fry, Mark J.,Nolan, Sheri,Okumu, Antony,Papa, Jonathan L.,Ratigan, Steven C.,Roth, Brieanna,Seffernick, Justin T.,Slayden, Richard A.,Vibhute, Sandip,Wozniak, Daniel J.,Yalowich, Jack
, p. 15214 - 15249 (2021/10/25)
Novel bacterial topoisomerase inhibitors (NBTIs) are among the most promising new antibiotics in preclinical/clinical development. We previously reported dioxane-linked NBTIs with potent antistaphylococcal activity and reduced hERG inhibition, a key safet
SUBSTITUTED 1-METHYL-1H-QUINOLIN-2-ONES AND 1-METHYL-1H-1,5-NAPHTHYRIDIN-2-ONES AS ANTIBACTERIALS
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Page/Page column 55, (2008/06/13)
Bicyclic nitrogen containing compounds of formula (I) and their use as antibacterials.
Pyrrolo[3,2,1-ij]quinoline-4-one derivatives for treating tuberculosis
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, (2008/12/04)
Tricyclic nitrogen-containing compounds of Formula (I) and pharmaceutically acceptable derivatives thereof: compositions containing them, their use in the treatment of tuberculosis, and methods for the preparation of such compounds.