1001519-38-5

Basic information

• Product Name: 4-CHLORO-1-METHYL-5-TRIFLUOROMETHYL-1 H-PYRAZOLE-3-CARBOXYLIC ACID
• Synonyms: 4-CHLORO-1-METHYL-5-TRIFLUOROMETHYL-1 H-PYRAZOLE-3-CARBOXYLIC ACID;AKOS B007425;ART-CHEM-BB B007425;4-Chloro-1-methyl-5-(trifluoromethyl)pyrazole-3-carboxylic acid;4-chloro-5-trifluoromethyl-1-methylpyrazole-3-carboxylic acid
• CAS NO: 1001519-38-5
• Molecular Formula: C6H4ClF3N2O2
• Molecular Weight: 228.56
• Mol File: 1001519-38-5.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 4-CHLORO-1-METHYL-5-TRIFLUOROMETHYL-1 H-PYRAZOLE-3-CARBOXYLIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 4-CHLORO-1-METHYL-5-TRIFLUOROMETHYL-1 H-PYRAZOLE-3-CARBOXYLIC ACID(1001519-38-5)
• EPA Substance Registry System: 4-CHLORO-1-METHYL-5-TRIFLUOROMETHYL-1 H-PYRAZOLE-3-CARBOXYLIC ACID(1001519-38-5)

Safety Data

• Hazardous Substances Data: 1001519-38-5(Hazardous Substances Data)

Upstream product

• 481065-92-3 1-methyl-5-(trifluoromethyl)-1H-pyrazole-3-carboxylic acid 

Relevant articles and documents

Improved regioselectivity in pyrazole formation through the use of fluorinated alcohols as solvents: Synthesis and biological activity of fluorinated tebufenpyrad analogs

(Chemical Equation Presented) The preparation of N-methylpyrazoles is usually accomplished through reaction of a suitable 1,3-diketone with methylhydrazine in ethanol as the solvent. This strategy, however, leads to the formation of regioisomeric mixtures of N-methylpyrazoles, which sometimes are difficult to separate. We have determined that the use of fluorinated alcohols such as 2,2,2-trifluoroethanol (TFE) and 1,1,1,3,3,3-hexafluoro-2-propanol (HFIP) as solvents dramatically increases the regioselectivity in the pyrazole formation, and we have used this modification in a straightforward synthesis of fluorinated analogs of Tebufenpyrad with acaricide activity.