1003221-10-0

Basic information

• Product Name: 5-benzyl-3-(3-bromophenyl)-1,2,4-oxadiazole
• Synonyms: HMS1624A14
• CAS NO: 1003221-10-0
• Molecular Formula: C14H9BrN2O
• Molecular Weight: 301.13806
• Mol File: 1003221-10-0.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 5-benzyl-3-(3-bromophenyl)-1,2,4-oxadiazole(CAS DataBase Reference)
• NIST Chemistry Reference: 5-benzyl-3-(3-bromophenyl)-1,2,4-oxadiazole(1003221-10-0)
• EPA Substance Registry System: 5-benzyl-3-(3-bromophenyl)-1,2,4-oxadiazole(1003221-10-0)

Safety Data

• Hazardous Substances Data: 1003221-10-0(Hazardous Substances Data)

Upstream product

• 1137-94-6 1-(2-phenyl-2-oxoethyl)pyridinium iodide 
• 16796-52-4 3-bromobenzene-1-carboximidamide hydrochloride 
• 108-88-3 toluene 
• 65-85-0 benzoic acid 
• 173406-70-7 3-bromo-N'-hydroxybenzenecarboximidamide 
• 98-88-4 benzoyl chloride 
• 6952-59-6 3-cyanobromobenzene 
• 3741-66-0 Ethyl benzoyl carbonate 

Downstream Products

• 1572343-36-2 3-(3-(9H-[3,9'-bicarbazol]-9-yl)phenyl)-5-phenyl-1,2,4-oxadiazole 

Relevant articles and documents

Direct synthesis of 3,5-diaryl-1,2,4-oxadiazoles using 1-(2-oxo-2-arylethyl)pyridin-1-iums with benzamidines

An efficient domino protocol for the synthesis of 1,2,4-oxadiazole derivatives from readily available 1-(2-oxo-2-arylethyl)pyridin-1-iums and amidine hydrochlorides was developed. In this practical approach, N-acyl amidine precursors were formed firstly via a simple nucleophilic substitution, without the purification of N-acylamidine intermediates, and the following intramolecularly dehydrative cyclization gave 1,2,4-oxadiazole derivatives in the presence of I2/K2CO3/DMSO, which exhibited excellent functional group tolerance and proceeded under simple experimental conditions.

A facile approach to synthesize 3,5-disubstituted-1,2,4-oxadiazoles via copper-catalyzed-cascade annulation of amidines and methylarenes

Various 3,5-disubstituted-1,2,4-oxadiazoles are smoothly formed via copper-catalyzed cascade annulation of amidines and methylarenes. This tandem oxidation-amination-cyclization transformation represents a straightforward protocol to prepare 1,2,4-oxadiazoles from easily available starting materials, with inexpensive copper catalysts and green oxidants. It has the advantages of atom- and step-economy, good functional group tolerance, as well as operational simplicity.