1004-36-0Relevant articles and documents
A novel method for the synthesis of 4H-pyran-4-one derivatives
Shahrisa,Tabrizi,Ahsani
, p. 47 - 55 (2000)
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Collie,Hilditch
, p. 787 (1907)
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Synthesis and Enantioselective Baeyer-Villiger Oxidation of Prochiral Perhydro-pyranones with Recombinant E. coli Producing Cyclohexanone Monooxygenase
Mihovilovic, Marko D.,Rudroff, Florian,Kandioller, Wolfgang,Gr?tzl, Birgit,Stanetty, Peter,Spreitzer, Helmut
, p. 1973 - 1976 (2003)
Recombinant whole cells of Escherichia coli overexpressing Adnetobacter sp. NCIMB 9871 cyclohexanone monooxygenase (E.C. 1.14.13.22) have been utilized for the Baeyer-Villiger oxidation of prochiral perhydro-pyranones. The spatial limitations of the enzym
Unusual aluminum chloride-assisted conversion of isopropenyl acetate into 3-acetyl- and 3,5-diacetyl-2,6-dimethyl-4H-pyran-4-ones
Novikov,Shestak,Denisenko
, p. 1600 - 1604 (2010)
Reflux of isopropenyl acetate with an excess of AlCl3 in 1,2-dichloroethane affords 3,5-diacetyl-2,6-dimethyl-4H-pyran-4-one in 17% yield. The mild acidic cleavage of the latter (2% HCl, 20°C, 16 h) gives 3-acetyl-2,6-dimethyl-4H-pyran-4-one in 87% yield, whereas this reaction under more drastic conditions (17% HCl, reflux, 3 h) gives 2,6-dimethyl-4H-pyran-4-one in 61% yield.
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Salvadori,Williams
, p. 2727 (1971)
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Cook
, p. 505,508, 510, 513 (1963)
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The Generation of a Library of Bromodomain-Containing Protein Modulators Expedited by Continuous Flow Synthesis
Filipponi, Paolo,Baxendale, Ian R.
, p. 2000 - 2012 (2016/04/26)
A continuous flow process delivering key building blocks for a series of BCP modulator libraries is reported. A dynamically mixed flow reactor emerged as a pivotal technology in both synthesis and isolation phases enabling the processing of slurries and suspensions while maintaining high productivity and reliability. Accordingly, the synthesis of common intermediates in flow were employed to further build a pyridazone-based library (36 compounds) aimed at improving lead compound potency and selectivity while further enabling structure-activity relationship studies of a new BCP modulator family.
Introduction of adjacent oxygen-functionalities in dimethyl heptalenedicarboxylates
Rogano, Frank,Stojnic, Danijela,Linden, Anthony,Abou-Hadeed, Khaled,Hansen, Hans-Juergen
experimental part, p. 1194 - 1215 (2011/09/14)
The bromination of dimethyl 8-methoxy-1,6,10-trimethylheptalene-4,5- dicarboxylate (6; Scheme 2) with N-bromosuccinimide (NBS) in N,N-dimethylformamide (DMF) leads in acceptable yields to the corresponding 9-bromoheptalenedicarboxylate 10 (Table 1). Ether