1004531-47-8

Basic information

• Product Name: C₁₉H₁₆F₃NO₃
• CAS NO: 1004531-47-8
• Molecular Weight: 363.336
• Mol File: 1004531-47-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₁₉H₁₆F₃NO₃(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₉H₁₆F₃NO₃(1004531-47-8)
• EPA Substance Registry System: C₁₉H₁₆F₃NO₃(1004531-47-8)

Safety Data

• Hazardous Substances Data: 1004531-47-8(Hazardous Substances Data)

Upstream product

• 90719-32-7 (S)-4-Benzyl-2-oxazolidinone 
• 2003-14-7 (3-trifluoromethyl-phenyl)-acetyl chloride 

Relevant articles and documents

Synthesis and SAR of succinamide peptidomimetic inhibitors of cathepsin S

Peptidic, non-covalent inhibitors of lysosomal cysteine protease cathepsin S (1 and 2) were investigated due to low oral bioavailability, leading to an improved series of peptidomimetic inhibitors. Utilizing phenyl succinamides as the P2 residue increased the oral exposure of this lead series of compounds, while retaining selective inhibition of the cathepsin S isoform. Concurrent investigation of the P1 and P2 subsites resulted in the discovery of several potent and selective inhibitors of cathepsin S with good pharmacokinetic properties due to the elimination of saturated aliphatic P2 residues.