1005036-73-6 Usage
Description
6,8-Difluoro-4-pyridin-3-yl-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinoline is a complex organic compound with a unique molecular structure that features a cyclopentaquinoline core fused with a pyridinyl ring. 6,8-Difluoro-4-pyridin-3-yl-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinoline is characterized by the presence of two fluorine atoms at the 6th and 8th positions, which may impart specific chemical properties and potential applications in various fields.
Uses
Used in Biochemical Research:
6,8-Difluoro-4-pyridin-3-yl-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinoline is used as an inhibitor in retrotransposition assays, which are essential for studying the molecular mechanisms of gene regulation and genetic recombination. Its ability to inhibit specific biochemical processes makes it a valuable tool for researchers in the field of molecular biology.
Used in Cellular Biology Applications:
In the context of cellular biology, 6,8-Difluoro-4-pyridin-3-yl-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinoline serves as an inhibitor of Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1 protein (GBF1) in HeLa cells. This application is crucial for understanding the role of GBF1 in cellular processes and its potential implications in various diseases. By inhibiting GBF1, researchers can investigate the effects on Golgi apparatus function and intracellular trafficking, which are critical for maintaining cellular homeostasis and proper functioning of the cell.
Biochem/physiol Actions
Golgicide A is a potent, highly specific, reversible inhibitor of the cis-Golgi ArfGEF GBF1. Arf proteins are members of the Ras superfamily of small guanosine triphosphatases (GTPases) that mediate vesicular transport. Golgicide A binds within an interfacial cleft formed between Arf1 and the GBF1 Sec7 domain. Golgicide A is a unique and powerful tool for further elucidating the mechanisms underlying assembly and transport within the Golgi, comparable to the use of dynasore for studying the dynamics of dynamin-mediated clathrin coat formation.
Check Digit Verification of cas no
The CAS Registry Mumber 1005036-73-6 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,0,0,5,0,3 and 6 respectively; the second part has 2 digits, 7 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 1005036-73:
(9*1)+(8*0)+(7*0)+(6*5)+(5*0)+(4*3)+(3*6)+(2*7)+(1*3)=86
86 % 10 = 6
So 1005036-73-6 is a valid CAS Registry Number.