1005342-46-0

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Basic information

Product Name: LCL-161
Synonyms: LCL-161;N-[(1S)-1-Cyclohexyl-2-{(2S)-2-[4-(4-fluorobenzoyl)-1,3-thiazol-2-yl]-1-pyrrolidinyl}-2-oxoethyl]-N2-MethylalaninaMide;(2S)-N-[(1S)-1-Cyclohexyl-2-[(2S)-2-[4-(4-fluorobenzoyl)-2-thiazolyl]-1-pyrrolidinyl]-2-oxoethyl]-2-(methylamino)-propanamide;N-[(1S)-1-cyclohexyl-2-[(2S)-2-[4-(4-fluorobenzoyl)-2-thiazolyl]-1-pyrrolidinyl]-2-oxoethyl]-2-(methylamino)-(2S)-propanamide;(2S)-N-[(1S)-1-Cyclohexyl-2-[(2S)-2-[4-(4-fluorobenzoyl)-2-thiazolyl]-1-pyrrolidinyl]-2-oxoethyl]-2-(methylamino)-propanamide LCL 161;(S)-N-((S)-1-Cyclohexyl-2-((S)-2-(4-(4-fluorobenzoyl)thiazol-2-yl)pyrrolidin-1-yl)-2-oxoethyl);LCL161, 98%, inhibitor of Apoptosis Protein (IAP) family of proteins
CAS NO:1005342-46-0
Molecular Formula: C₂₆H₃₃FN₄O₃S
Molecular Weight: 500.6286232
EINECS: N/A
Product Categories: Inhibitors
Mol File: 1005342-46-0.mol
Article Data: 2

Chemical Properties

Melting Point: N/A
Boiling Point: 713.7±60.0 °C(Predicted)
Flash Point: N/A
Appearance: /
Density: 1.245±0.06 g/cm3(Predicted)
Refractive Index: N/A
Storage Temp.: N/A
Solubility: ≥25.05 mg/mL in DMSO; insoluble in H2O; insoluble in EtOH
PKA: 14.25±0.46(Predicted)
CAS DataBase Reference: LCL-161(CAS DataBase Reference)
NIST Chemistry Reference: LCL-161(1005342-46-0)
EPA Substance Registry System: LCL-161(1005342-46-0)

Safety Data

Hazard Codes: N/A
Statements: N/A
Safety Statements: N/A
RIDADR: 3077
WGK Germany:
RTECS:
HazardClass: N/A
PackingGroup: N/A
Hazardous Substances Data: 1005342-46-0(Hazardous Substances Data)

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Factory Price API 99% LCL-161 1005342-46-0 GMP Manufacturer
Cas No: 1005342-46-0
USD $ 0.1-0.1 / Gram
1 Gram
100 Metric Ton/Year
Xi'an Xszo Chem Co., Ltd.
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LCL161
Cas No: 1005342-46-0
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Hangzhou J&H Chemical Co., Ltd.
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Factory Price API 99% LCL-161 1005342-46-0 GMP Manufacturer CAS NO.1005342-46-0
Cas No: 1005342-46-0
USD $ 10.0-100.0 / Gram
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Wuhan Xinhao Biotechnology Co., Ltd.
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1005342-46-0 high purity LCL161
Cas No: 1005342-46-0
USD $ 100.0-100.0 / Gram
10 Gram
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Zibo Hangyu Biotechnology Development Co., Ltd
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LCL161;N-[(1S)-1-cyclohexyl-2-[(2S)-2-[4-(4-fluorobenzoyl)-2-thiazolyl]-1-pyrrolidinyl]-2-oxoethyl]-2-(methylamino)-(2S)-propanamide
Cas No: 1005342-46-0
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Xiamen Jenny Chemical Technology Co., Ltd.
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SAGECHEM/ LCL161/SAGECHEM/Manufacturer in China
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SAGECHEM LIMITED
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LCL-161
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Senova Technology Company Limited
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N-[(1S)-1-Cyclohexyl-2-{(2S)-2-[4-(4-fluorobenzoyl)-1,3-thiazol-2-yl]-1-pyrrolidinyl}-2-oxoethyl]-N2-methylalaninamide cas no. 1005342-46-0 98%
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Win-Win chemical Co.Ltd
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LCL-161
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Suzhou Sibian Chemical Technology Co., Ltd
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1005342-46-0 Usage

Description

LCL-161 is a small molecule Smac mimetic that inhibits multiple inhibitor of apoptosis (IAP) family proteins.

Uses

LCL 161 is a second mitochondria-derived activator of caspases (SMAC) inhibitor used to prolong patient survival by increasing apoptosis of anti-tumor drugs.

Check Digit Verification of cas no

The CAS Registry Mumber 1005342-46-0 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,0,0,5,3,4 and 2 respectively; the second part has 2 digits, 4 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 1005342-46:
(9*1)+(8*0)+(7*0)+(6*5)+(5*3)+(4*4)+(3*2)+(2*4)+(1*6)=90
90 % 10 = 0
So 1005342-46-0 is a valid CAS Registry Number.

1005342-46-0SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 15, 2017

Revision Date: Aug 15, 2017

1.Identification

1.1 GHS Product identifier

Product name	N-[(1S)-1-Cyclohexyl-2-{(2S)-2-[4-(4-fluorobenzoyl)-1,3-thiazol-2-yl]-1-pyrrolidinyl}-2-oxoethyl]-N²-methylalaninamide

1.2 Other means of identification

Product number	-
Other names	N1-(1H-benzimidazol-2-ylmethyl)-N1-(5,6,7,8-tetrahydro-quinolin-8-yl)-butane-1,4-diamine

1.3 Recommended use of the chemical and restrictions on use

Identified uses	For industry use only.
Uses advised against	no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number	-
Service hours	Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:1005342-46-0 SDS

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1005342-46-0Relevant articles and documents

SOLID ORAL FORMULATIONS AND CRYSTALLINE FORMS OF AN INHIBITOR OF APOPTOSIS PROTEIN

-

, (2011/02/24)

The present disclosure relates to crystalline form of (S)-N-((S)-1- cyclohexyl-2-{(S)-2-[4-(4-fluoro-benzoyl)-thiazol-2-yl]-pyrrolidin-1-yl}-2-oxo-ethyl)- 2-methylamino-propionamide, salts and hydrates thereof. This disclosure also relates to solid oral f

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