1006-33-3

Basic information

• Product Name: 2'-BROMO-5'-FLUOROACETOPHENONE
• Synonyms: 2'-BROMO-5'-FLUOROACETOPHENONE;1-(2-bromo-5-fluorophenyl)ethanone;1-(2-Bromo-5-fluorophenyl)ethan-1-one;Ethanone,1-(2-bromo-5-fluorophenyl)-;Acetophenone, 2'-bromo-5'-fluoro-
• CAS NO: 1006-33-3
• Molecular Formula: C₈H₆BrFO
• Molecular Weight: 217.04
• Product Categories: Adehydes, Acetals & Ketones;Bromine Compounds;Fluorine Compounds
• Mol File: 1006-33-3.mol
• Article Data: 24

Chemical Properties

• Boiling Point: 144℃/18mm
• Appearance: /
• Density: 1.535±0.06 g/cm3(Predicted)
• Refractive Index: 1.5525
• Storage Temp.: Sealed in dry,Room Temperature
• Solubility: Soluble in methanol.
• CAS DataBase Reference: 2'-BROMO-5'-FLUOROACETOPHENONE(CAS DataBase Reference)
• NIST Chemistry Reference: 2'-BROMO-5'-FLUOROACETOPHENONE(1006-33-3)
• EPA Substance Registry System: 2'-BROMO-5'-FLUOROACETOPHENONE(1006-33-3)

Safety Data

• Hazardous Substances Data: 1006-33-3(Hazardous Substances Data)

Usage

Description

2'-BROMO-5'-FLUOROACETOPHENONE is an organic compound that serves as a key intermediate in the synthesis of various chemical compounds. It is characterized by its unique molecular structure, which includes a bromo and fluoro substituent on the acetophenone backbone.

Uses

Used in Chemical Synthesis:
2'-BROMO-5'-FLUOROACETOPHENONE is used as a synthetic intermediate for the production of oxabicyclic compounds. Its unique structure allows for the formation of these complex molecules, which have potential applications in various fields, including pharmaceuticals and materials science.
Additionally, 2'-BROMO-5'-FLUOROACETOPHENONE is used as a key component in the enantioselective synthesis of chiral 3-aryl-1-indanone molecules. These chiral molecules are important in the development of enantiomerically pure compounds, which are crucial for various applications, such as pharmaceuticals, agrochemicals, and fragrances. The enantioselective synthesis of these molecules using 2'-BROMO-5'-FLUOROACETOPHENONE allows for the creation of optically active compounds with specific biological activities and properties.

Upstream product

• 394-28-5 2-Bromo-5-fluorobenzoic acid 
• 75-16-1 methylmagnesium bromide 
• 676-58-4 methylmagnesium chloride 
• 57381-39-2 2-bromo-5-fluorobenzonitrile 
• 94569-84-3 2-bromo-5-fluorobenzaldehyde 
• 906673-56-1 1-(2′-bromo-5′-fluorophenyl)ethan-1-ol 
• 1246078-73-8 methyl 3-(2-bromo-5-fluorophenyl)-3-oxopropionate 
• 313547-14-7 2-bromo-5-fluoro-N-methoxy-N-methylbenzamide 

Downstream Products

• 1246078-71-6 1-(2-bromo-5-fluorophenyl)-3-(dimethylamino)prop-2-en-1-one 
• 1380424-26-9 6-fluoro-1,2-diphenylquinolin-4(1H)-one 
• 1374227-76-5 5-fluoro-3-methyl-1-phenyl-1H-indazole 
• 1379534-72-1 C₁₆H₂₅FOSi₂ 
• 1427446-94-3 2-bromo-1-(2-bromo-5-fluorophenyl)ethan-1-one 

Relevant articles and documents

Asymmetric Synthesis and Application of Chiral Spirosilabiindanes

Reported here is the development of a class of chiral spirosilabiindane scaffolds by Rh-catalyzed asymmetric double hydrosilation, for the first time. Enantiopure SPSiOL (spirosilabiindane diol), a new type of chiral building block for the preparation of various chiral ligands and catalysts, was readily prepared on greater than 10 gram scale using this protocol. The potential of this new spirosilabiindane scaffold in asymmetric catalysis was preliminarily demonstrated by development of the corresponding monodentate phosphoramidite ligands (SPSiPhos), which were used in both a Rh-catalyzed hydrogenation and a Pd-catalyzed intramolecular carboamination.

Intramolecular One-Carbon Homologation of Unstrained Ketones via C-C Activation-Enabled 1,1-Insertion of Alkenes

Here, we describe the development of a Rh-catalyzed intramolecular one-carbon homologation of unstrained aryl ketones through a formal 1,1-insertion process of olefins, enabled by temporary directing group (TDG)-aided C-C activation. The reaction provides a distinct approach to access various substituted 1-indanones. Computational mechanistic studies reveal that the formal 1,1-insertion is realized by a selective C(sp2)-C(sp3) activation and turnover limiting 2,1-insertion into the alkene, followed by a facile β-H elimination and reinsertion process.

Divergent Access to Benzocycles through Copper-Catalyzed Borylative Cyclizations

A copper-catalyzed chemodivergent approach to five- and six-membered benzocycles from dienyl arenes tethered with a ketone has been developed. Through proper choice of coordinating ligands and catalytic conditions, copper-catalyzed borylative cyclization of a single dienyl arene can be diverted to two different pathways, leading to indanols and dihydronaphthalenols with high stereoselectivity. The chiral bidentate bisphosphine ligand (S,S)-Ph-BPE was optimal for asymmetric copper-allyl addition to a tethered ketone via a boat-like transition state, whereas NHC ligands led to boro-allyl addition producing indanols with high diastereoselectivity. (Figure presented.).

NOVEL 6,7-DIHYDRO-4H-PYRAZOLO[1,5-A]PYRAZINE INDOLE-2-CARBOXAMIDES ACTIVE AGAINST THE HEPATITIS B VIRUS (HBV)

The present invention relates generally to novel antiviral agents. Specifically, the present invention relates to compounds which can inhibit the protein(s) encoded by hepatitis B virus (HBV) or interfere with the function of the HBV replication cycle, compositions comprising such compounds, methods for inhibiting HBV viral replication, methods for treating or preventing HBV infection, and processes and intermediates for mating the compounds.