100603-74-5

Basic information

• Product Name: 2'-<((2,2,2-trichloroethyl)oxy)carbonyl>-7-oxotaxol
• CAS NO: 100603-74-5
• Molecular Weight: 1027.3
• Mol File: 100603-74-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2'-<((2,2,2-trichloroethyl)oxy)carbonyl>-7-oxotaxol(CAS DataBase Reference)
• NIST Chemistry Reference: 2'-<((2,2,2-trichloroethyl)oxy)carbonyl>-7-oxotaxol(100603-74-5)
• EPA Substance Registry System: 2'-<((2,2,2-trichloroethyl)oxy)carbonyl>-7-oxotaxol(100603-74-5)

Safety Data

• Hazardous Substances Data: 100603-74-5(Hazardous Substances Data)

Upstream product

• 100431-55-8 2'-<((2,2,2-trichloroethyl)oxy)carbonyl>taxol 

Downstream Products

• 100431-56-9 7-oxotaxol 
• 100431-61-6 7-oxo-5,6-dehydro-5,O-secotaxol 
• 100431-62-7 Benzoic acid (1S,2S,3R,4S,6R,9S)-6-acetoxy-3-((S)-3-acetoxy-6-oxo-tetrahydro-pyran-3-yl)-9-((2R,3S)-3-benzoylamino-2-hydroxy-3-phenyl-propionyloxy)-1-hydroxy-4,8,11,11-tetramethyl-5-oxo-bicyclo[5.3.1]undec-7-en-2-yl ester 

Relevant articles and documents

Modified Taxols. 2. Oxidation Products of Taxol

Oxidation of taxol (1) or substituted taxols with Jones' reagent under appropriate conditions yielded 7-oxotaxol (6), 2',7'-dioxotaxol (9), or 2'-oxo-7-acetyltaxol (12).Treatment of 7-oxotaxol with DBU or silica gel yielded a D-secotaxol derivative 14.Hydrogenation of the 2'-acetate derivative of 14 yielded the unstable diketone 16, while hydrogenation of 14 itself followed by workup in methanol gave the lactone 17.