1007089-84-0

Basic information

• Product Name: 3-(chloromethyl)-5-methylpyridine hydrochloride
• Synonyms: 3-(chloromethyl)-5-methylpyridine hydrochloride
• CAS NO: 1007089-84-0
• Molecular Formula: C7H9Cl2N
• Molecular Weight: 178.05906
• Mol File: 1007089-84-0.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 232.233 °C at 760 mmHg
• Flash Point: 116.576 °C
• Appearance: /
• Density: 1.118 g/cm³
• Storage Temp.: Refrigerator
• Solubility: DMSO (Slightly), Methanol (Slightly), Water (Slightly)
• CAS DataBase Reference: 3-(chloromethyl)-5-methylpyridine hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(chloromethyl)-5-methylpyridine hydrochloride(1007089-84-0)
• EPA Substance Registry System: 3-(chloromethyl)-5-methylpyridine hydrochloride(1007089-84-0)

Safety Data

• Hazardous Substances Data: 1007089-84-0(Hazardous Substances Data)

Usage

Uses

3-Chloromethyl-5-methylpyridine is an intermediate in the synthesis of Rupatadine (R701650).

Upstream product

• 102074-19-1 (5-methylpyridin-3-yl)methanol 
• 29681-45-6 5-methylnicotinic acid methyl ester 
• 591-22-0 3,5-Lutidine 

Relevant articles and documents

Expedient synthesis of rupatadine

Rupatadine, a new potent, orally active dual antagonist of histamine and platelet-activating factor (PAF), has been synthesized in 91% overall yield. Copyright Taylor & Francis Group, LLC.

Preparation process of Rupatadine

The invention discloses a rupatadine preparation process, which comprises: S1, preparing methyl 5-methylnicotinate; S2, preparing 5-methyl-3-pyridinemethanol; S3, preparing 3-methyl-5-chloromethylpyridine hydrochloride; and S4, preparing rupatadine. According to the present invention, the preparation process has advantages of low cost, mild reaction condition, simple operation, low requirement onequipment, good product purity and high yield, and is suitable for large-scale industrial production.

4H- [1, 2, 4] TRIAZOLO [5, 1 -B] PYRIMIDIN-7 -ONE DERIVATIVES AS CCR2B RECEPTOR ANTAGONISTS

The present invention relates to novel compounds for use in the compositions, to processes for their preparation, to intermediates useful in their preparation and to their use as therapeutic agents. The present invention also relates to pharmaceutical com