100784-85-8

Basic information

• Product Name: 5-(4-Chloro-phenyl)-3-phenyl-pyrrole-1,2-dicarboxylic acid diethyl ester
• Synonyms: 5-(4-Chloro-phenyl)-3-phenyl-pyrrole-1,2-dicarboxylic acid diethyl ester
• CAS NO: 100784-85-8
• Molecular Weight: 397.858
• Mol File: 100784-85-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 5-(4-Chloro-phenyl)-3-phenyl-pyrrole-1,2-dicarboxylic acid diethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 5-(4-Chloro-phenyl)-3-phenyl-pyrrole-1,2-dicarboxylic acid diethyl ester(100784-85-8)
• EPA Substance Registry System: 5-(4-Chloro-phenyl)-3-phenyl-pyrrole-1,2-dicarboxylic acid diethyl ester(100784-85-8)

Safety Data

• Hazardous Substances Data: 100784-85-8(Hazardous Substances Data)

Upstream product

• 100784-67-6 diethyl 5-(p-chlorophenyl)-3-phenyl-3,4-dihydro-2H-pyrrole-2,2-dicarboxylate 
• 956-02-5 4'-chlorochalcone 

Downstream Products

• 100784-93-8 ethyl 5-(4-chlorophenyl)-3-phenyl-1H-pyrrole-2-carboxylate 
• 100784-96-1 5-(4-Chloro-phenyl)-3-phenyl-1H-pyrrole-2-carboxylic acid methyl ester 

Relevant articles and documents

The Synthesis and Chemistry of Azolenines. Part 4. Preparation and Rearrangement of some 3,5-Diaryl-2H-pyrrole-2,2-dicarboxylic Esters

Oxidation of diethyl 3,5-diaryl-3,4-dihydro-2H-pyrrole-2,2-dicarboxylates (3) with chloranil in refluxing xylene gives not the 3,5-diaryl-2H-pyrrole-2,2-dicarboxylates (4) as reported by an earlier group, but instead the rearranged, isomeric, 1H-pyrrole-1,2-dicarboxylates (5). 2H-Pyrroles (4) may be obtained from the dihydropyrroles (3) using DDQ in benzene at room temperature; they rearrange to the isomers (5) in boiling xylene via an acyl -sigmatropic shift from carbon to nitrogen, a novel process in the 2H-pyrrole series.Thermal analyses indicate that the rearrangement is concerted with negligible charge separation in the transition state.Other novel 3,5-diaryl-1H-pyrrole-2-carboxylic acid derivatives are described.