1008361-76-9Relevant articles and documents
Selective synthesis of 7-substituted purines via 7,8-dihydropurines
Kotek, Vladislav,Chudikova, Nadezda,Tobrman, Tomas,Dvorak, Dalimil
supporting information; experimental part, p. 5724 - 5727 (2011/03/19)
A simple and efficient protocol for the preparation of 7-substituted purines is described. 6- and 2,6-Dihalopurines were N9-tritylated and then transformed to 7,8-dihydropurines by DIBAL-H. Subsequent N 7-alkylation followed by N9-trityl deprotection with trifluoroacetic acid was accompanied by spontaneous reoxidation, which led to the 7-substituted purines at 55 - 88% overall isolated yields.